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IMA107

a PET radioligand for PDE10A; structure in first source

Also Known As:

(11C)IMA107

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - IMA107: 2
    - IMA107: 2

Experts

1.	Niccolini, Flavia: 2 articles (06/2016 - 01/2016)
2.	Politis, Marios: 2 articles (06/2016 - 01/2016)
3.	Pagano, Gennaro: 1 article (06/2016)
4.	Gunn, Roger N: 1 article (01/2016)
5.	Howes, Oliver: 1 article (01/2016)
6.	Kapur, Shitij: 1 article (01/2016)
7.	Marques, Tiago Reis: 1 article (01/2016)
8.	Natesan, Sridhar: 1 article (01/2016)
9.	Rabiner, Eugenii A: 1 article (01/2016)
10.	Searle, Graham E: 1 article (01/2016)

Related Diseases

1.	Disease Progression 06/01/2016 - "Brain metabolism ([(18)F]FDG and [(15)O]H2O), presynaptic ([(18)F]fluorodopa, [(11)C]β-CIT and [(11)C]DTBZ) and postsynaptic ([(11)C]SCH22390, [(11)C]FLB457 and [(11)C]raclopride) dopaminergic function, phosphodiesterases ([(18)F]JNJ42259152, [(18)F]MNI-659 and [(11)C]IMA107), and adenosine ([(18)F]CPFPX), cannabinoid ([(18)F]MK-9470), opioid ([(11)C]diprenorphine) and GABA ([(11)C]flumazenil) receptors were evaluated as potential biomarkers for monitoring disease progression and for assessing the development and efficacy of novel disease-modifying drugs in premanifest HD carriers and HD patients. "
2.	Schizophrenia (Dementia Praecox) 01/01/2016 - "There was no significant difference in [(11)C]IMA107 BPND between schizophrenia patients and comparison subjects in any of the brain regions studied (thalamus, caudate, putamen, nucleus accumbens, globus pallidus, and substantia nigra). " 01/01/2016 - "The authors compared PDE10A availability in the brains of 12 patients with chronic schizophrenia and 12 matched healthy comparison subjects using [(11)C]IMA107 positron emission tomography (PET). " 01/01/2016 - "Using a newly developed and validated radioligand, [(11)C]IMA107, the authors report the first in vivo assessment of PDE10A brain expression in patients with schizophrenia. " 01/01/2016 - "Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107."

Related Drugs and Biologics

1.	Phosphoric Diester Hydrolases (Phosphodiesterases)
2.	Raclopride
3.	Biomarkers (Surrogate Marker)
4.	gamma-Aminobutyric Acid (GABA)
5.	Flumazenil (Romazicon)
6.	Diprenorphine
7.	Cannabinoids
8.	Opioid Analgesics (Opioids)
9.	Adenosine (Adenocard)
10.	2- ((4- (1- (2- fluoroethyl)- 4- (4- pyridinyl)- 1H- pyrazol- 3- yl)phenoxy)methyl)- 3,5- dimethylpyridine