[Experimental validation of the use of the radioprotector indometofen for inflammation arrest in the periodontium in an immunodeficiency state].

Abstract

Grave inflammatory destructive lesions of the periodontium were induced in rats by ligature of canine pericervical area and cyclophosphamide injection. Histological analysis showed regression of inflammatory destructive changes on days 20 and 30 in the majority of animals injected indometaphene after the above experimental exposure but no regression in animals injected no indometaphene.

• Authors: A S Grigor'ian, A I Volozhin, E V Shuntikova, L A Kozhevnikova
• Journal: Patologicheskaia fiziologiia i eksperimental'naia terapiia (Patol Fiziol Eksp Ter) 1998 Jul-Sep Issue 3 Pg. 15-8 ISSN: 0031-2991 [Print] Russia (Federation)
• Vernacular Title: Eksperimental'noe obosnovanie primeneniia radioprotektora indometofena dlia kupirovaniia vospaleniia v parodonte pri immunodefitsitnom sostoianii.
• PMID: 9819551 (Publication Type: English Abstract, Journal Article)

Chemical References

• Radiation-Protective Agents
• indometafen
• Tamoxifen

Topics

• Animals
• Drug Evaluation, Preclinical
• Immune Tolerance (drug effects)
• Periodontitis (drug therapy)
• Radiation-Protective Agents (therapeutic use)
• Rats
• Tamoxifen (analogs & derivatives, therapeutic use)