Cytokines in the modulation of eosinophilia.

Abstract

In this review we discuss our recently results showing interleukin 5 (IL-5) involvement in eosinophil migration and in the maintenance of eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a visceral larva migrans syndrome model using guinea-pigs infected with Toxocara canis. We also describe the sequential release of TNF-alpha and IL-8 during the course of infection. Finally we propose a biological role for IL-5, at least in our model, as a modulator of IL-8 release and secretion.

• Authors: L H Faccioli, B B Vargaftig, A I Medeiros, A Malheiros
• Journal: Memorias do Instituto Oswaldo Cruz (Mem Inst Oswaldo Cruz) Vol. 92 Suppl 2 Pg. 109-14 ( 1997) ISSN: 0074-0276 [Print] Brazil
• PMID: 9698922 (Publication Type: Journal Article, Review)

Chemical References

• Cytokines

Topics

• Animals
• Cytokines (physiology)
• Eosinophilia (immunology)
• Eosinophils (physiology)
• Guinea Pigs
• Larva Migrans, Visceral (immunology)
• Toxocara canis (immunology)