Visceral Larva Migrans

A condition produced in man by the prolonged migration of animal nematode larvae in extraintestinal tissues other than skin; characterized by persistent hypereosinophilia, hepatomegaly, and frequently pneumonitis, commonly caused by Toxocara canis and Toxocara cati.

Also Known As:

Networked: 74 relevant articles (4 outcomes, 4 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Toxocariasis
2.	Eosinophilia
3.	Parasitic Diseases (Parasitic Disease)
4.	Myiasis (Myiases)
5.	Granuloma

Experts

1.	Nawa, Yukifumi: 3 articles (01/2006 - 06/2002)
2.	Agatsuma, Takeshi: 2 articles (09/2008 - 03/2007)
3.	Rajapakse, R P V J: 2 articles (09/2008 - 03/2007)
4.	Akao, Nobuaki: 2 articles (01/2006 - 11/2005)
5.	Bottieau, Emmanuel: 1 article (03/2015)
6.	Clerinx, Jan: 1 article (03/2015)
7.	Jacobs, Jan: 1 article (03/2015)
8.	Kanobana, Kirezi: 1 article (03/2015)
9.	Polman, Katja: 1 article (03/2015)
10.	Soentjens, Patrick: 1 article (03/2015)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Visceral Larva Migrans:

1.	AntigensIBA 09/01/2004 - "Ascaris suum larval excretory-secretory (AsES) antigen and larval (AsLA) as well as adult somatic antigen (AsAA) which were thought to be possibly helpful in the diagnosis of visceral larva migrans (VLM) due to A. " 07/01/2008 - "canis larvae and a simple method for the production of Toxocara ES antigen for the uses in serodiagnostic tests for visceral larva migrans. " 03/01/2007 - "Characterization of a Toxocara canis species-specific excretory-secretory antigen (TcES-57) and development of a double sandwich ELISA for diagnosis of visceral larva migrans." 09/01/2001 - "A Western blotting procedure with excretory/secretory antigens from Toxocara canis larvae was developed for immunodiagnosis of visceral larva migrans in mice. " 09/01/2001 - "Application of western blotting procedure for the immunodiagnosis of visceral larva migrans in mice by using excretory/secretory antigens."
2.	EnzymesIBA 06/01/2002 - "The diagnosis of visceral larva migrans (VLM) was made based on the positive results in enzyme-linked immunosorbent assay for Toxocara canis together with clinical symptoms and laboratory data. " 08/01/2007 - "Diagnosis of human toxocariosis: visceral larva migrans depends on antibody detection against excretions-secretions (E/S) from Toxocara larvae by enzyme-linked immunosorbent assay. " 04/01/1990 - "We report three cases of children with visceral larva migrans confirmed by enzyme-linked immunosorbent assay (ELISA), in Goiânia. " 06/01/1987 - "Thirty-seven adults living in the Midi-Pyrenees region of France were confirmed as having visceral larva migrans based on an increased specific antibody titer to Toxocara canis as detected by enzyme-linked immunosorbent assay (ELISA) and by the Western blot method. " 01/01/1979 - "The enzyme-linked immunosorbent assay (ELISA) using Toxocara canis larva-specific antigens was used to confirm a presumptive clinical diagnosis of visceral larva migrans in patients whose serum specimens were submitted to the Center for Disease Control. "
3.	ImmunosorbentsIBA 06/01/2002 - "The diagnosis of visceral larva migrans (VLM) was made based on the positive results in enzyme-linked immunosorbent assay for Toxocara canis together with clinical symptoms and laboratory data. " 08/01/2007 - "Diagnosis of human toxocariosis: visceral larva migrans depends on antibody detection against excretions-secretions (E/S) from Toxocara larvae by enzyme-linked immunosorbent assay. " 04/01/1990 - "We report three cases of children with visceral larva migrans confirmed by enzyme-linked immunosorbent assay (ELISA), in Goiânia. " 06/01/1987 - "Thirty-seven adults living in the Midi-Pyrenees region of France were confirmed as having visceral larva migrans based on an increased specific antibody titer to Toxocara canis as detected by enzyme-linked immunosorbent assay (ELISA) and by the Western blot method. " 01/01/1979 - "The enzyme-linked immunosorbent assay (ELISA) using Toxocara canis larva-specific antigens was used to confirm a presumptive clinical diagnosis of visceral larva migrans in patients whose serum specimens were submitted to the Center for Disease Control. "
4.	Thiabendazole (Mintezol)FDA Link 02/01/1975 - "Thiabendazole treatment of presumptive visceral larva migrans (VLM)." 07/19/1971 - "Thiabendazole effects in visceral larva migrans." 03/01/1971 - "Thiabendazole in visceral larva migrans." 09/01/1979 - "Thiabendazole therapy is probably worth trying for early ophthalmic involvement with visceral larva migrans if the organism is still alive. " 11/01/1969 - "Thiabendazole therapy in visceral larva migrans. "
5.	Hemagglutinins (Hemagglutinin)IBA 01/01/1985 - "These antigens may cross-react with elevated concentrations of A and B isohemagglutinins in some patients and give false-positive results in the serologic diagnosis of visceral larva migrans caused by T. " 01/01/1985 - "Do Toxocara canis larval antigens used in enzyme-linked immunosorbent assay for visceral larva migrans cross-react with AB isohemagglutinins and give false positive results?"
6.	AntibodiesIBA 01/01/2015 - "Immunoblot for the detection of Ascaris suum-specific antibodies in patients with visceral larva migrans (VLM) syndrome." 09/01/1993 - "The laboratory test results for visceral larva migrans (VLM) using ELISA for Toxocara canis antibodies employed by the Institute for Medical Research, Kuala Lumpur, is described. " 04/01/1977 - "Larva-specific antibodies in patients with visceral larva migrans." 01/01/1976 - "The detection of antibodies in subjects with visceral larva migrans syndrome caused by Toxocara canis is usually carried out with antigenic larvae, whose preparation presents some difficulties. " 04/01/2007 - "The aim of this investigation was to study the frequency of visceral larva migrans (VLM) granulomas in autopsies at a Children's Reference Hospital in Vitoria, ES Brazil, where anti-Toxocara antibodies are frequently detected in the serum of children admitted at the hospital. "
7.	Interleukin-5 (Interleukin 5)IBA 01/01/1996 - "IL-5 drives eosinophils from bone marrow to blood and tissues in a guinea-pig model of visceral larva migrans syndrome." 01/01/1996 - "This study was undertaken to evaluate the role of IL-5 in eosinophil migration and in the maintenance of eosinophilia in a guinea-pig model of visceral larva migrans syndrome. " 01/01/1997 - "In this review we discuss our recently results showing interleukin 5 (IL-5) involvement in eosinophil migration and in the maintenance of eosinophilia in blood, bone marrow, lung and peritoneal cavity, in a visceral larva migrans syndrome model using guinea-pigs infected with Toxocara canis. "
8.	Ivermectin (Mectizan)FDA Link 01/01/2005 - "Clinical trials are under way to evaluate the activity of ivermectin on nematodes (Loa loa, Mansonella sp., intestinal nematodes, cutaneous and visceral larva migrans) and ectoparasites (Pediculus humanus capitis, Phtirius pubis, Tunga penetrans, myiases). " 10/01/2001 - "Examples include thiabendazole for cutaneous larva migrans, mebendazole for ascariasis, trichiuriasis and hookworm, albendazole for inoperable cases of cystic hydatid disease, DEC for Toxocara induced visceral larva migrans and loiasis, ivermectin for onchocerciasis, praziquantel for schistosomiasis and niridazole for Dracunculus medinensis. "
9.	Indicators and Reagents (Reagents)IBA 10/01/2014 - "Similarly, in parasitic infections related to larva migrans (visceral, cutaneous, ocular), the eosinophils level is again a primary indicator and its evident cause is the roundworm Toxocara spp. The aim of this study was to evaluate the significance characteristics of Toxocara spp. in patients with eosonophilia. "
10.	Immunoglobulin G (IgG)IBA 09/01/2008 - "Development of a highly sensitive IgG-ELISA based on recombinant arginine kinase of Toxocara canis for serodiagnosis of visceral larva migrans in the murine model." 01/01/2006 - "Eventually she transpired to have a high IgG antibody titer against excretory-secretary (ES) antigen of Ascaris suum larvae, but not of Toxocara canis larvae, suggesting that she had been suffering from visceral larva migrans (VLM) caused by A. " 04/01/2001 - "ELISA showed 10% with visceral larva migrans & 65.5% with toxoplasmosis (IgG, IgM or both). " 09/01/1980 - "A 3-year-old girl had the typical features of visceral larva migrans syndrome, including hypereosinophilia, recurrent pulmonary infiltrates, and elevated serum IgG, IgE, and isohemagglutinin titers. " 01/01/1982 - "In sera from patients with visceral larva migrans (VLM) syndrome, enzyme-linked immunospecific assay (ELISA) was used to detect IgG and IgE antibody anti-excretory-secretory antigen (ESA) from the second larval stage of Toxocara canis. "

Therapies and Procedures

1.	Therapeutics 01/01/2010 - "Identification of abundant Charcot-Leyden crystals and necrotic eosinophils in an FNA of the liver led to appropriate ancillary diagnostic tests and therapy for visceral larva migrans." 09/01/1998 - "This is a case of visceral larva migrans and hypereosinophilia syndrome with persistently elevated white blood cell count despite adequate medical therapy in a 4-year-old boy with leukocytosis and splenomegaly. " 07/18/2012 - "Because of the difficulty in making a definite diagnosis, anthelmintic therapy should be performed in patients with a suspected diagnosis of visceral larva migrans based on their epidemic history and presence of typical manifestations, especially when the serological test results are negative. " 04/01/1994 - "Hepatic visceral larva migrans: evolution of the lesion, diagnosis, and role of high-dose albendazole therapy." 09/01/1979 - "Thiabendazole therapy is probably worth trying for early ophthalmic involvement with visceral larva migrans if the organism is still alive. "
2.	Palliative Care (Palliative Therapy) 02/01/1977 - "For example, in visceral larva migrans, caused by the dog roundworm Toxocara canis, only palliative therapy with systemic anti-inflammatory agents and corticosteroids may be helpful. "
3.	Aftercare (After-Treatment) 04/01/1984 - "canis may account for the clinical improvement observed after treatment with thiabendazole in cases of visceral larva migrans, the prevention of prenatal or mammary transmission of infection in dogs, and the suppression of tissue damage by nematode larvae in general."