Altered response to stimuli of the AP-1/DNA binding activity in a syndrome of precocious ageing (geroderma osteodysplastica hereditaria).

Abstract

Cell senescence produces changes in the expression of specific genes, suggesting that senescent cells express an altered pattern of transcription factors. Here we describe how the DNA binding activity of the activator protein 1(AP-1) complex is altered in the fibroblasts of a geroderma osteodysplastica patient in response to extracellular stimuli.

• Authors: R Gherzi, C Bellini, E Bonioli
• Journal: Mechanisms of ageing and development (Mech Ageing Dev) Vol. 100 Issue 2 Pg. 169-75 (Jan 30 1998) ISSN: 0047-6374 [Print] Ireland
• PMID: 9541137 (Publication Type: Journal Article)

Chemical References

• DNA-Binding Proteins
• Transcription Factor AP-1

Topics

• Aging (metabolism)
• Child, Preschool
• DNA-Binding Proteins (metabolism)
• Female
• Fibroblasts (metabolism)
• Humans
• Syndrome
• Transcription Factor AP-1 (metabolism)