Abstract | PURPOSE:
Dequalinium, a drug known for over 30 years, is a dicationic amphiphile compound resembling bolaform electrolytes. The purpose of our work was to determine the state of aggregation of dequalinium in aqueous medium and to investigate both, its ability to bind DNA and its potential to serve as a novel non-viral transfection vector. METHODS: RESULTS: CONCLUSIONS: Based on the intrinsic properties of dequalinium such as the in vivo selectivity for carcinoma cells and selective accumulation in mitochondria we propose DQAsomes as a novel and unique drug and gene delivery system.
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Authors | V Weissig, J Lasch, G Erdos, H W Meyer, T C Rowe, J Hughes |
Journal | Pharmaceutical research
(Pharm Res)
Vol. 15
Issue 2
Pg. 334-7
(Feb 1998)
ISSN: 0724-8741 [Print] United States |
PMID | 9523323
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Infective Agents, Local
- Drug Carriers
- Liposomes
- Dequalinium
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Topics |
- Animals
- Anti-Infective Agents, Local
(administration & dosage)
- Cell Line
- Dequalinium
(administration & dosage)
- Drug Carriers
- Drug Delivery Systems
- Freeze Fracturing
- Liposomes
- Microscopy, Electron
- Particle Size
- Transfection
(methods)
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