Abstract | OBJECTIVE: We recently reported that thyroid-stimulating blocking antibody ( TSBAb) may not contribute to the development of hypothyroidism more than six years after 131I treatment. In the present study, we attempted to determine whether hypothyroidism that develops within a shorter period of time following 131I therapy is associated with TSBAb. DESIGN: Retrospective study. PATIENTS: Sera were obtained from 8 patients who developed hypothyroidism within 6 months after 131I therapy (Group 1), 8 patients who became euthyroid one year after 131I therapy (Group 2), and 7 patients who developed transient hypothyroidism (Group 3). MEASUREMENTS: RESULTS: At about 3 months after 131I treatment, TSAb activity increased significantly in Groups 2 and 3, but did not change in Group 1. In contrast, TSBAb activity in Group 1 increased significantly and was positive in 6 patients at that time. At 12-18 months after 131I treatment, TSBAb activity tended to decrease and remained positive in 3 patients but became negative in 3 patients. It did not change in the patients in Groups 2 and 3. The patients in Group 1 were treated with levothyroxine, 75-125 micrograms/day. Levothyroxine was discontinued in the 3 patients whose TSBAb activity disappeared. Two of them remained euthyroid, and 1 became hypothyroid. CONCLUSION: Results indicate that the hypothyroidism that develops within a short time after 131I treatment may be caused by TSBAb activity. Thyroid function may be recovered when TSBAb activity disappears.
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Authors | K Yoshida, Y Aizawa, N Kaise, H Fukazawa, Y Kiso, N Sayama, H Hori, N Nakazato, J Tani, K Abe |
Journal | Clinical endocrinology
(Clin Endocrinol (Oxf))
Vol. 48
Issue 1
Pg. 17-22
(Jan 1998)
ISSN: 0300-0664 [Print] England |
PMID | 9509063
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
- Autoantibodies
- Immunoglobulins, Thyroid-Stimulating
- Iodine Radioisotopes
- Receptors, Thyrotropin
- thyrotropin-binding inhibitory immunoglobulin
- Thyrotropin
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Topics |
- Analysis of Variance
- Autoantibodies
(blood)
- Graves Disease
(radiotherapy)
- Humans
- Hypothyroidism
(immunology)
- Immunoglobulins, Thyroid-Stimulating
(immunology)
- Iodine Radioisotopes
(adverse effects, therapeutic use)
- Middle Aged
- Receptors, Thyrotropin
(blood)
- Retrospective Studies
- Thyrotropin
(immunology)
- Time Factors
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