Effect of pivagabine on stress-induced gastric ulcer formation in rats.

Abstract

In this study the efficacy of pivagabine (4-[(2,2-dimethyl-1-oxopropyl)amino]butanoic acid, CAS 69542-93-4, Tonerg) in preventing experimental stress ulcer in animals was evaluated. Twenty Wistar rats were randomly subdivided into 2 groups; one group received pivagabine (200 mg/kg orally) and the other tap water. The rats were immobilized in a cold room (2-4 degrees C) for 2 h, and the number and extension of gastric ulcerative and hemorrhagic lesions were evaluated. Pivagabine determined a significant reduction in the number of animals with gastric lesions (5 vs. 10, p < 0.05), in the linear extension of ulcers (2.0 +/- 0.8 vs. 7.2 +/- 1.7 mm, percent protection 72.2, p < 0.05) and in the linear extension of hemorrhages (2.6 +/- 1.0 vs. 10.3 +/- 1.6 mm, percent protection 74.8, p < 0.01). The protective effect of pivagabine on experimental stress-induced ulcers is likely to be mediated by the inhibition of corticotropin releasing factor release from hypothalamus, as also suggested by behavioral studies.

• Authors: A M Gianni, G Bruno, C Sirtori
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 47 Issue 11A Pg. 1315-7 (Nov 1997) ISSN: 0004-4172 [Print] Germany
• PMID: 9450155 (Publication Type: Journal Article)

Chemical References

• Psychotropic Drugs
• gamma-Aminobutyric Acid
• pivagabine

Topics

• Animals
• Cold Temperature
• Immobilization
• Male
• Psychotropic Drugs (pharmacology)
• Rats
• Rats, Wistar
• Stomach Ulcer (etiology, prevention & control)
• Stress, Psychological (complications)
• gamma-Aminobutyric Acid (analogs & derivatives, pharmacology)