Phosphatidylethanolamine methylation and hepatoma cell growth.

Abstract

Phosphatidylethanolamine is converted to phosphatidylcholine in hepatocytes via the enzyme phosphatidylethanolamine N-methyltransferase (PEMT). An isoform, PEMT2 has been cloned, expressed and localized to a mitochondria-associated membrane in rat liver. Expression of PEMT2 caused a decreased rate of cell division of cultured rat hepatoma cells. Mechanistic studies suggest that the slower growth of transfected hepatoma cells may be due to down regulation of CTP: phosphocholine cytidylyltransferase and the CDP-choline pathway for phosphatidylcholine biosynthesis. A role for PEMT2 in the regulation of hepatocyte cell division is also indicated by PEMT2 down-regulation in regenerating rat liver.

• Authors: D E Vance, M Houweling, M Lee, Z Cui
• Journal: Anticancer research (Anticancer Res) 1996 May-Jun Vol. 16 Issue 3B Pg. 1413-6 ISSN: 0250-7005 [Print] Greece
• PMID: 8694509 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)

Chemical References

• Phosphatidylethanolamines
• Methyltransferases
• Phosphatidylethanolamine N-Methyltransferase
• Nucleotidyltransferases
• Choline-Phosphate Cytidylyltransferase

Topics

• Animals
• Cell Division
• Choline-Phosphate Cytidylyltransferase
• Liver Neoplasms, Experimental (metabolism, pathology)
• Methylation
• Methyltransferases (physiology)
• Nucleotidyltransferases (metabolism)
• Phosphatidylethanolamine N-Methyltransferase
• Phosphatidylethanolamines (metabolism)
• Rats