Cytidine Diphosphate Choline (Citicoline)

Donor of choline in biosynthesis of choline-containing phosphoglycerides.

Also Known As:

Citicoline; CDP Choline; Cidifos; Citicholine; Cyticholine; Cytidine 5'-Diphosphocholine; 5'-Diphosphocholine, Cytidine; Choline, CDP; Choline, Cytidine Diphosphate; Cytidine 5' Diphosphocholine; Diphosphate Choline, Cytidine; Cytidine 5'-(trihydrogen diphosphate), P'-(2-(trimethylammonio)ethyl) ester, inner salt

Networked: 564 relevant articles (106 outcomes, 215 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Parisi, Vincenzo: 12 articles (03/2021 - 01/2005)
2.	Manni, Gianluca: 11 articles (03/2021 - 01/2008)
3.	Secades, Julio J: 10 articles (04/2021 - 12/2002)
4.	Adibhatla, Rao Muralikrishna: 10 articles (03/2013 - 01/2002)
5.	Cansev, Mehmet: 9 articles (12/2021 - 05/2003)
6.	Cotroneo, Antonino Maria: 8 articles (01/2022 - 01/2012)
7.	Gareri, Pietro: 8 articles (01/2022 - 01/2012)
8.	Castagna, Alberto: 8 articles (04/2021 - 01/2012)
9.	Oddone, Francesco: 8 articles (03/2021 - 01/2008)
10.	Roberti, Gloria: 8 articles (03/2021 - 05/2014)

Related Diseases

1.	Stroke (Strokes) 09/01/2012 - "CDP-choline at high doses is as effective as i.v. thrombolysis in experimental animal stroke." 09/01/1997 - "When the baseline NIH stroke scale was used as a covariate, both the 500-mg citicoline group and the 2,000-mg citicoline group had a significant improvement in terms of the percent of patients who had a favorable outcome on the Barthel Index at 90 days. " 04/01/2009 - "Evaluation of a sequential global test of improved recovery following stroke as applied to the ICTUS trial of citicoline." 01/01/2013 - "Cognitive functions improved 6 and 12 months after stroke in the entire group but in comparison with controls, citicoline-treated patients showed better outcome in attention-executive functions (OR 1.721, 95% CI 1.065-2.781, p = 0.027 at 6 months; OR 2.379, 95% CI 1.269-4.462, p = 0.007 at 12 months) and temporal orientation (OR 1.780, 95% CI 1.020-3.104, p = 0.042 at 6 months; OR 2.155, 95% CI 1.017-4.566, p = 0.045 at 12 months) during the follow-up. " 01/01/2002 - "Randomized clinical stroke treatment trials performed outside of the United States (US) have shown promising results but several recent US trials have failed to support the use of citicoline following middle cerebral artery (MCA) stroke. "
2.	Ischemic Stroke 11/01/2013 - "Citicoline in the treatment of acute ischaemic stroke: an international, randomized, multicentre, placebo-controlled study (ICTUS trial) is the use of Citicoline is beneficial for acute ischaemic stroke?" 09/01/2012 - "From these results, we conclude that high-dose CDP-choline may be an effective treatment for acute ischaemic stroke even in absence of thrombolysis." 04/01/2009 - "Oral citicoline improved neurological, functional and global outcomes in patients with acute ischemic stroke without significant safety concerns." 01/01/2016 - "The review presents data on the evaluation of the efficacy of citicoline in ischemic stroke. " 01/01/2016 - "To evaluate the effect of citicoline on the efficacy of rehabilitation measures in patients with ischemic stroke (IS). "
3.	Glaucoma 09/23/2022 - "The combination of oral treatment with DHA + citicoline significantly improved VF indices and their slopes in patients with glaucoma after 3 months of treatment." 01/01/2016 - "Commentary: Citicoline: A Food Beneficial for Patients Suffering from or Threated with Glaucoma." 01/01/2016 - "Citicoline: A Food Beneficial for Patients Suffering from or Threated with Glaucoma." 01/15/2002 - "A few reports indicate that citicoline treatment may also be beneficial in glaucoma. " 03/18/2020 - "Citicoline (cytidine 5'-diphosphocholine) is a naturally occurring endogenous compound that has been investigated as a novel therapeutic agent for the management of glaucoma. "
4.	Cognitive Dysfunction 11/01/2023 - "Citicoline significantly enhanced neurite outgrowth in Neuro-2a cells, and the combination of citicoline and NMN remarkably induced neurite outgrowth in Neuro-2a cells and primary cortical neuronal cells with an optimal proportion of 4:1. In the rat model of BCCAO, when two drugs in combination of 160 mg/kg citicoline and 40 mg/kg NMN, this combination administrated at 7 days post-BCCAO significantly improved the cognitive impairment in BCCAO rats compared with vehicle group by the analysis of the Morris water maze and the novel object recognition test. " 01/01/2003 - "The efficacy of long-term citicoline treatment for cognitive impairment and neuropathological decline in those patients already meeting criteria for VaD does not appear to be substantiated by the current study." 09/01/2006 - "Citicoline also improved the mnesic and cognitive disorders seen after HT of minor severity that constitute the so-called post-concussional syndrome. " 01/01/2021 - "The aim of the observational program was to study the effect of the use of the drug recognan (citicoline) on the state of higher mental functions (memory, attention, visual-motor coordination, dynamic praxis,verbal thinking and imagination) in patients with mild cognitive impairment. " 01/01/2021 - "The aim of the study was to study the effect of the drug recognan (citicoline) on the neurodynamic characteristics of mental activity in patients with mild cognitive impairment. "
5.	Memory Disorders (Memory Loss) 05/15/2015 - "Citicoline improved memory deficits at the two times tested, while physical exercise only in the long-term test. " 01/01/2021 - "The findings suggest that regular consumption of citicoline may be safe and potentially beneficial against memory loss due to aging. " 11/01/2006 - "We have previously shown that chronic, but not acute, dietary supplementation with CDP-choline prevents the hippocampal-dependent memory deficits manifested by aged rats and by rats reared under impoverished environmental conditions. " 01/01/2006 - "Nevertheless, citicoline has proved to be a valid treatment in patients with a cerebrovascular pathogenesis for memory disorders. " 04/01/1997 - "According to the present results, showing that citicoline improves memory performance in elderly subjects, we concluded that this molecule is suitable for the treatment of memory deficits in old people."

Related Drugs and Biologics

1.	Cytidine Diphosphate Choline (Citicoline)
2.	Neuroprotective Agents
3.	Choline (Choline Chloride)
4.	Cytidine
5.	Phospholipids (Phosphatides)
6.	Phosphatidylcholines (Phosphatidylcholine)
7.	Retinaldehyde (Retinal)
8.	Erythropoietin
9.	Memantine (Namenda)
10.	Liposomes (Liposome)

Related Therapies and Procedures

1.	Therapeutics
2.	Off-Label Use
3.	Length of Stay
4.	Oral Administration
5.	Intravenous Injections