HI-6 therapy and the acute phase response in the rat.

Abstract

The propensity of therapeutic doses of HI-6 (50 mg/kg) in combination with atropine sulphate (17 mg/kg), antidotes used to treat organophosphate poisoning, to induce the acute phase response (APR) in the laboratory rat was examined. A single intraperitoneal injection of HI-6, either alone or with atropine, caused a rapid doubling of the plasma corticosterone concentration. However, this increase was short-lived in comparison with corticosterone kinetics during the typical, turpentine-induced APR. The elevated glucocorticosteroid concentration did not affect acute phase protein (APP) gene transcription or mRNA and protein synthesis in the livers of oxime/atropine-treated rats. On the basis of these findings, we concluded that the administered doses of HI-6 and atropine did not induce the generalised, non-specific APR.

• Authors: S Ivanović-Matić, G Poznanović
• Journal: Toxicology (Toxicology) Vol. 106 Issue 1-3 Pg. 11-7 (Jan 08 1996) ISSN: 0300-483X [Print] Ireland
• PMID: 8571381 (Publication Type: Journal Article)

Chemical References

• Acute-Phase Proteins
• Antidotes
• Blood Proteins
• Oximes
• Pyridinium Compounds
• RNA, Messenger
• Atropine
• Soman
• asoxime chloride
• Corticosterone
• Turpentine

Topics

• Acute-Phase Proteins (biosynthesis, genetics)
• Acute-Phase Reaction (chemically induced)
• Animals
• Antidotes (administration & dosage, therapeutic use, toxicity)
• Atropine (administration & dosage, therapeutic use, toxicity)
• Blood Proteins (biosynthesis)
• Blotting, Northern
• Corticosterone (blood)
• Immunoelectrophoresis
• Injections, Intraperitoneal
• Liver (metabolism)
• Male
• Oximes
• Pyridinium Compounds (administration & dosage, therapeutic use, toxicity)
• RNA, Messenger (analysis)
• Rats
• Rats, Wistar
• Soman (poisoning)
• Turpentine (toxicity)