Thymosin fraction 5 does not influence urinary tract carcinogenesis by phenacetin and N-butyl-N-(4-hydroxybutyl)nitrosamine in NON/Shi mice.

Abstract

The effect of thymosin fraction 5 (TF5) on the promotion and progression phases of urinary tract carcinogenesis induced by consecutive administration of phenacetin and N-butyl-N-(4-hydroxybutyl)-nitrosamine (BBN) in NON/Shi mice was investigated. The study was carried out twice with a minor modification to the protocol in the second experiment. Fifty-seven male NON/Shi mice in experiment 1 and 100 mice in experiment 2 were each divided into four groups. Phenacetin was administered for 8 weeks in experiment 1 and 12 weeks in experiment 2, and subsequently BBN was given for 6 weeks in both cases, for total observation periods of 30 and 34 weeks, respectively. Sixty micrograms of TF5 per mouse was inoculated subcutaneously twice a week during (group 2) or after (group 3) BBN exposure, or both periods (group 4). Group 1 served as a control group without TF5 treatment. Histopathological examination revealed no effects on either induction of urinary tract carcinomas or distant metastasis from renal pelvic carcinomas in either experiment.

• Authors: T Murai, H Iwata, S Mori, F Hato, S Kimura, Y Kinoshita, S Wada, T Kishimoto, S Makino, T Oohara
• Journal: Oncology research (Oncol Res) Vol. 7 Issue 3-4 Pg. 139-44 ( 1995) ISSN: 0965-0407 [Print] United States
• PMID: 8555647 (Publication Type: Journal Article)

Chemical References

• Carcinogens
• Phytohemagglutinins
• thymosin fraction 5
• Concanavalin A
• Butylhydroxybutylnitrosamine
• Thymosin
• Phenacetin

Topics

• Animals
• Butylhydroxybutylnitrosamine (toxicity)
• Carcinogens (toxicity)
• Cocarcinogenesis
• Concanavalin A (pharmacology)
• Drug Interactions
• Lymphocytes (drug effects, immunology)
• Male
• Mice
• Mice, Inbred Strains
• Phenacetin (toxicity)
• Phytohemagglutinins (pharmacology)
• Spleen (cytology, drug effects, immunology)
• Thymosin (analogs & derivatives, toxicity)
• Urologic Neoplasms (chemically induced)