Increase in the level of mRNA for 3-hydroxyanthranilate 3,4-dioxygenase in brain of epilepsy-prone El mice.

Abstract

We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3,4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.

• Authors: Y Nakagawa, H Asai, J Kitoh, H Mori, K Nakano
• Journal: Bioscience, biotechnology, and biochemistry (Biosci Biotechnol Biochem) Vol. 59 Issue 11 Pg. 2191-2 (Nov 1995) ISSN: 0916-8451 [Print] England
• PMID: 8541664 (Publication Type: Journal Article)

Chemical References

• RNA, Messenger
• Oxygenases
• Dioxygenases
• 3-Hydroxyanthranilate 3,4-Dioxygenase
• Quinolinic Acid

Topics

• 3-Hydroxyanthranilate 3,4-Dioxygenase
• Animals
• Brain (enzymology, metabolism)
• Dioxygenases
• Epilepsy (enzymology, genetics)
• Genetic Predisposition to Disease
• Mice
• Molecular Sequence Data
• Oxygenases (genetics)
• Quinolinic Acid (metabolism)
• RNA, Messenger (genetics, metabolism)