HOME PRODUCTS SERVICES COMPANY CONTACT FAQ

Quinolinic Acid

Subscribe to New Research on Quinolinic Acid

A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.

Also Known As:

Quinolinic Acid, Copper(2+) Salt; Quinolinic Acid, Disodium Salt; Quinolinic Acid, Strontium Salt; Quinolinate; 2,3-Pyridinedicarboxylic acid

Networked: 468 relevant articles (15 outcomes, 36 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 25
- 1-Ring Heterocyclic Compounds
  - Pyridines: 30
    - Quinolinic Acids: 3
      - Quinolinic Acid: 468
        6-hydroxyquinolinic acid

Experts

1.	Guillemin, Gilles J: 12 articles (01/2010 - 01/2002)
2.	Brew, Bruce J: 11 articles (07/2009 - 01/2002)
3.	Souza, Diogo O: 8 articles (02/2010 - 08/2003)
4.	Schmidt, André P: 6 articles (01/2008 - 08/2003)
5.	Heyes, Melvyn P: 6 articles (06/2006 - 07/2002)
6.	Schwarcz, Robert: 5 articles (02/2010 - 01/2003)
7.	Guidetti, Paolo: 5 articles (02/2010 - 01/2003)
8.	Popoli, Patrizia: 5 articles (09/2007 - 03/2002)
9.	Kumar, Puneet: 4 articles (08/2010 - 11/2009)
10.	Kumar, Anil: 4 articles (08/2010 - 11/2009)

Related Diseases

1.	Huntington Disease (Huntington's Disease) 11/01/2000 - "Intrastriatal injection of quinolinate has been proven to be a very useful animal model to study the pathogenesis and treatment of Huntington's disease. " 12/01/2003 - "Deficits induced by quinolinic acid lesion to the striatum in a position discrimination and reversal task are ameliorated by permanent and temporary lesion to the globus pallidus: a potential novel treatment in a rat model of Huntington's disease." 03/16/1998 - "Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease." 02/15/2010 - "Intrastriatal injection of quinolinic acid (QUIN) to rodents reproduces some biochemical, morphological, and behavioral characteristics of Huntington's disease. " 02/09/2010 - "Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease." Order ALL the reference details at left...
2.	Seizures (Seizure) 01/01/1986 - "The effect of pretreatment with drugs on generalized clonic-tonic seizures induced by intracerebroventricular (i.c.v.) administration of the endogenous convulsant quinolinic acid (QUIN, 50 micrograms) was studies in rats. " 10/01/1995 - "Animals that were given quinolinate did not display behavioral seizures, and showed preferential degeneration of neurons in layer V of the entorhinal cortex. " 06/01/1995 - "Quinolinic acid (QA) induced clonic and tonic convulsions in mice when it was injected into the cerebral ventricle. " 07/01/1994 - "Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. " 04/01/1993 - "The unilateral intrahippocampal injection of 120 nmol of quinolinic acid induced seizures together with local neurodegeneration in specific cell layers. " Order ALL the reference details at left...
3.	Body Weight (Weight, Body) 01/01/2010 - "The optimal dose of Ksheerabala was found from a dose escalation study, wherein it was found that Ksheerabala showed maximum protection against quinolinic acid-induced neurotoxicity at a dose of 15 microL/100 g body weight/day, which was selected for further experiments. " 01/01/2010 - "Four groups of female albino rats were maintained for 21 days as follows: 1. Control group, 2. Quinolinic acid (55 microg/100 g body weight), 3. Ksheerabala (15 microL/100 g body weight), 4. Ksheerabala (15 microL/100 g body weight) + Quinolinic acid (55 microg/100 g body weight). " 10/01/1997 - "In gerbils, systemic immune activation by an intraperitoneal injection of endotoxin (1 mg/kg of body weight) increased quinolinate levels in brain, blood, lung, liver, and spleen, with proportional increases in lung indoleamine-2,3-dioxygenase activity at 24 h postinjection. " 04/01/2009 - "As judged from in increase of urinary quinolinic acid and nicotinic acid as indices of metabolic change, NOAEL was 0.1% in diet, corresponding to 90 mg/kg body weight/day, and the lowest-observed-adverse-effect-level (LOAEL) was 0.3% in diet, corresponding to 270 mg/kg body weight/day." 10/01/1996 - "We retrospectively evaluated the association of change in body weight with changes in neurocognitive function, ventricular brain ratio, and cerebrospinal quinolinic acid levels in a small cohort of children (n=15; mean age 6.3 years) with symptomatic HIV-1 disease before and after 6 months of antiretroviral therapy with continuous intravenous infusion of zidovudine (ZVD). " Order ALL the reference details at left...
4.	Otitis Media with Effusion 06/01/2010 - "Our study investigated the neurotoxicity of quinolinic acid (QA) to spiral ganglion cells (SGCs), observed the protective effects of N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 and magnesium ions on the QA-induced injury to SGCs, and analyzed the role of QA in otitis media with effusion (OME)-induced sensorineural hearing loss (SNHL). " Order ALL the reference details at left...
5.	Sensorineural Hearing Loss 06/01/2010 - "Our study investigated the neurotoxicity of quinolinic acid (QA) to spiral ganglion cells (SGCs), observed the protective effects of N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 and magnesium ions on the QA-induced injury to SGCs, and analyzed the role of QA in otitis media with effusion (OME)-induced sensorineural hearing loss (SNHL). " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Kynurenine
2.	N-Methylaspartate (NMDA)
3.	Neurotoxins
4.	Tryptophan (L-Tryptophan)
5.	Dizocilpine Maleate (Dizocilpine)
6.	Magnesium
7.	Carbon Monoxide
8.	Ions
9.	atorvastatin (Lipitor)
10.	gamma-Aminobutyric Acid (GABA)

Related Therapies and Procedures

1.	Injections
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Intraperitoneal Injections
5.	Therapeutics

blog comments powered by Disqus

TREATMENT OPTIONS
for Huntington Disease,
Ranking and Evidence

CureHunter Patient-Physician Summary Reports collect in one document all the medications ever reported in the US National Library of Medicine—1949 to the present—to be effective against your target disease. Analytic charts allow you and your physicians to see at a glance the treatment options—including new, promising, off-label and experimental.

Free Updates for 1 Year
All 106 Outcomes
Top 200 Key Drugs and Biologics
Top 50 Key Therapies and Procedures
Detailed History Charts
Full Research Evidence References
Sample PDF Report on Psoriasis >>

Price:

$8.50 USD & Delivery via PDF download
updates for 1 year

Research Interface PRO

Rapidly retrieve clinical outcome summaries for all evidence of drug efficacy against any disease in seconds. Click "Charts" to view graphs of relative efficacy of all drugs against any known disease. CureHunter is unlike any "search engine" you have ever used. Where standard "search engines" produce lists of links, CureHunter quantifies evidence, extracts it from the literature and calculates a result you can use to immediately facilitate evidence based decision making in Real Clinical Time. Save hours of search and analysis time:

Two-clicks from Disease to Drug to Evidence: Drill down to full abstract
Enable Experts: Quickly identify key researchers and their publications
Enable FDA Link Generic: Two-clicks to FDA Products/Patents/Generics
Enable Export: All outcome statements and scores exportable to Excel/TSV for automated meta-analysis
Research Network: Explore drug and disease relationships visually
Enable Mobile Interface: Access from your cellphone, iPhone or PDA

Price:

$45.00 USD access via web interface
1 year subscription

Request Bulk Institution License Details >>