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Quinolinic Acid

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A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS.

Also Known As:

Quinolinic Acid, Copper(2+) Salt; Quinolinic Acid, Disodium Salt; Quinolinic Acid, Strontium Salt; Quinolinate; 2,3-Pyridinedicarboxylic acid

Networked: 464 relevant articles (11 outcomes, 34 trials/studies) for this Bio-Agent, Comments

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 25
- 1-Ring Heterocyclic Compounds
  - Pyridines: 28
    - Quinolinic Acids: 3
      - Quinolinic Acid: 464
        6-hydroxyquinolinic acid

Experts

1.	Guillemin, Gilles J: 12 articles (01/2010 - 01/2002)
2.	Brew, Bruce J: 11 articles (07/2009 - 01/2002)
3.	Souza, Diogo O: 8 articles (02/2010 - 08/2003)
4.	Schmidt, André P: 6 articles (01/2008 - 08/2003)
5.	Heyes, Melvyn P: 6 articles (06/2006 - 07/2002)
6.	Schwarcz, Robert: 5 articles (02/2010 - 01/2003)
7.	Guidetti, Paolo: 5 articles (02/2010 - 01/2003)
8.	Popoli, Patrizia: 5 articles (09/2007 - 03/2002)
9.	Pawlak, Dariusz: 4 articles (09/2009 - 01/2003)
10.	Santamaría, Abel: 4 articles (05/2009 - 07/2003)

Related Diseases

1.	Seizures (Seizure) 01/01/1986 - "The effect of pretreatment with drugs on generalized clonic-tonic seizures induced by intracerebroventricular (i.c.v.) administration of the endogenous convulsant quinolinic acid (QUIN, 50 micrograms) was studies in rats. " 10/01/1995 - "Animals that were given quinolinate did not display behavioral seizures, and showed preferential degeneration of neurons in layer V of the entorhinal cortex. " 06/01/1995 - "Quinolinic acid (QA) induced clonic and tonic convulsions in mice when it was injected into the cerebral ventricle. " 07/01/1994 - "Previous investigations in seizure-prone mice have suggested that an abnormally elevated production of the astrocyte-derived neuroexcitant, quinolinic acid (QUIN), plays a role in seizure susceptibility. " 04/01/1993 - "The unilateral intrahippocampal injection of 120 nmol of quinolinic acid induced seizures together with local neurodegeneration in specific cell layers. " Order ALL the reference details at left...
2.	Huntington Disease (Huntington's Disease) 11/01/2000 - "Intrastriatal injection of quinolinate has been proven to be a very useful animal model to study the pathogenesis and treatment of Huntington's disease. " 12/01/2003 - "Deficits induced by quinolinic acid lesion to the striatum in a position discrimination and reversal task are ameliorated by permanent and temporary lesion to the globus pallidus: a potential novel treatment in a rat model of Huntington's disease." 03/16/1998 - "Electrolytic lesion of globus pallidus ameliorates the behavioral and neurodegenerative effects of quinolinic acid lesion of the striatum: a potential novel treatment in a rat model of Huntington's disease." 02/15/2010 - "Intrastriatal injection of quinolinic acid (QUIN) to rodents reproduces some biochemical, morphological, and behavioral characteristics of Huntington's disease. " 02/09/2010 - "Of mice, rats and men: Revisiting the quinolinic acid hypothesis of Huntington's disease." Order ALL the reference details at left...
3.	Nervous System Diseases (Neurological Disorders) 05/31/2005 - "Quinolinate has also been implicated in important neurological disorders. " 06/01/2001 - "Because minor changes in the physiological concentrations of 3OH-kynurenine and quinolinic acid may cause neuronal death, our data suggest that these metabolites play a key role in the pathogenesis of several neurological disorders." 04/01/1996 - "Quinolinic acid (Quin) is thought to underlie cognitive and motor dysfunctions for a variety of neurological disorders. " 10/01/1997 - "Quinolinic acid (QUIN) has been associated with several inflammatory neurologic disorders, including AIDS dementia complex (ADC). " 06/30/1999 - "It was subsequently shown that a robust activation of the kynurenine pathway and a large accumulation of quinolinic acid in the central nervous system occurred in several inflammatory neurological disorders. " Order ALL the reference details at left...
4.	Anoxia (Hypoxia) 10/01/2003 - "On the contrary, c-fos-positive profiles decreased in the substantia nigra pars reticulata of the quinolinic acid-injected animals after the preconditioning hypoxia. " 10/01/1990 - "In addition, 45 also protected gerbils from hippocampal neuronal degeneration produced by either hypoxia or intrastriatal quinolinic acid injection." 10/01/2003 - "By counting the number of tyrosine hydroxylase-stained neurons and c-fos-positive nuclei a short period after injection of quinolinic acid into the striatum, we observed that hypoxia induced a more marked decrease in the number of tyrosine hydroxylase-stained neurons. " 01/01/2001 - "It is also proposed that the role of iNOS induction during CM is protective: that the primary purpose of iNOS induction is to inhibit the side effects of brain indoleamine 2,3-dioxygenase (IDO) induction and quinolinic acid accumulation during hypoxia." 01/01/1995 - "We have examined organotypic rat brain cultures maintained under standard conditions, and subsequently exposed to anoxia and neurotoxins: kainic and quinolinic acid. " Order ALL the reference details at left...
5.	Parkinsonian Disorders (Parkinsonism) 10/01/1997 - "Huntington's, Parkinsonism, Down's syndrome) quinolinic acid and/or kynurenic acid concentrations are altered, suggesting the ratio of these chemicals may be important in neurodegeneration. " 07/01/2000 - "In the present experiment we studied the ability of embryonic striatal grafts to protect against striatal quinolinic acid (QA)-induced excitotoxicity in a previously established double lesion rat model of striatonigral degeneration (SND), the neuropathological substrate of parkinsonism associated with multiple system atrophy (MSA). " 08/01/1999 - "To determine the feasibility and clinical efficacy of convective drug delivery for treatment of a neurological disorder, the investigators selectively ablated globus pallidus internus (GPi) neurons with quinolinic acid (QA), an excitotoxin, in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced model of primate parkinsonism. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Kynurenine
2.	Neurotoxins
3.	Tryptophan (L-Tryptophan)
4.	Carbon Monoxide
5.	atorvastatin (Lipitor)
6.	gamma-Aminobutyric Acid (GABA)
7.	Anticonvulsants (Antiepileptic Drugs)
8.	1- Methyl- 4- phenyl- 1,2,3,6- tetrahydropyridine (MPTP)
9.	Sodium
10.	4-amino-3-phenylbutyric acid (phenibut)

Related Therapies and Procedures

1.	Injections
2.	Transplants (Transplant)
3.	Transplantation (Transplant Recipients)
4.	Intraperitoneal Injections
5.	Therapeutics

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