Abstract | BACKGROUND: Little is understood about reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin. OBJECTIVE: Our purpose was to define reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin further with focus on immunologic studies. METHODS: In patients with reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin, we measured circulating immune complexes before, during, and after therapy. We examined natural killer cells in a functional assay; we performed direct immunofluorescence and T- and B-cell marker studies in skin biopsy specimens. RESULTS: The infiltrate in reticular erythematous mucinosis is composed of helper T cells. Circulating immune complexes are increased in both reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin and decrease with hydroxychloroquine therapy and clinical clearing. Natural killer cell function is decreased in reticular erythematous mucinosis and Jessner's lymphocytic infiltrate of skin. CONCLUSION:
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Authors | S W Braddock, H D Kay, D Maennle, T L McDonald, S J Pirruccello, A Masih, L W Klassen, A R Sawka |
Journal | Journal of the American Academy of Dermatology
(J Am Acad Dermatol)
Vol. 28
Issue 5 Pt 1
Pg. 691-5
(May 1993)
ISSN: 0190-9622 [Print] United States |
PMID | 8496412
(Publication Type: Case Reports, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Antibody-Dependent Cell Cytotoxicity
(immunology)
- Antigen-Antibody Complex
(analysis)
- Blood Vessels
(pathology)
- Erythema
- Female
- Hair
(pathology)
- Humans
- Hyperplasia
- Killer Cells, Lymphokine-Activated
(immunology, pathology)
- Killer Cells, Natural
(immunology, pathology)
- Lymphocytes
(immunology, pathology)
- Lymphoid Tissue
(immunology, pathology)
- Male
- Middle Aged
- Mucinoses
(immunology, pathology)
- Skin
(blood supply)
- Skin Diseases, Papulosquamous
(immunology, pathology)
- T-Lymphocyte Subsets
(immunology, pathology)
- T-Lymphocytes, Cytotoxic
(immunology, pathology)
- T-Lymphocytes, Helper-Inducer
(immunology, pathology)
- T-Lymphocytes, Regulatory
(immunology, pathology)
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