Effects of serine protease inhibitor FOY-305 and heparin on the growth of squamous cell carcinoma.

Abstract

Effects of serine proteinase inhibitor FOY-305 and heparin on autochthonous skin carcinoma were examined using ddY female mice with single tumor induced by methylcholanthrene. FOY-305 given intraperitoneally for 9 consecutive weeks inhibited the growth of the pre-existing dermal tumors. Heparin alone was equally therapeutically effective. However, heparin induced severe mucocutaneous bleeding of the gastrointestinal mucosa. In contrast, the combined administration of FOY-305 and heparin suppressed tumor growth without any visible side effects. There was a significant increase in well differentiated cancer cells in mice treated with FOY-305 and heparin in combination, suggesting that co-administration of FOY-305 and heparin may be useful for the treatment of squamous cell carcinoma.

• Authors: M Ohkoshi, T Akagawa, M Nakajima
• Journal: Anticancer research (Anticancer Res) 1993 Jul-Aug Vol. 13 Issue 4 Pg. 963-6 ISSN: 0250-7005 [Print] Greece
• PMID: 8352567 (Publication Type: Journal Article)

Chemical References

• Esters
• Guanidines
• Serine Proteinase Inhibitors
• camostat
• Gabexate
• Methylcholanthrene
• Heparin

Topics

• Animals
• Body Weight (drug effects)
• Carcinoma, Squamous Cell (chemically induced, pathology)
• Cell Division (drug effects)
• Esters
• Female
• Gabexate (analogs & derivatives)
• Guanidines (pharmacology, therapeutic use)
• Heparin (pharmacology, toxicity)
• Methylcholanthrene
• Mice
• Mice, Inbred Strains
• Serine Proteinase Inhibitors (pharmacology)
• Skin Neoplasms (chemically induced, pathology)
• Time Factors