Endothelin-1-induced gastric ulcer is attenuated by cetraxate.

Abstract

We investigated the effect of the anti-ulcer drug cetraxate on the development of the gastric ulcer induced by the submucosal injection of endothelin-1 in the rat gastric body, and its effects on gastric mucosal hemodynamics and tissue oxygenation by Laser doppler flowmetry and tissue spectrophotometry. Endothelin-1 induced gastric ulcer (ulcer length: 11.85 +/- 0.89 mm, mean +/- SEM, n = 4) which was strongly attenuated by cetraxate (ulcer length: 3.27 +/- 0.3 mm, mean +/- SEM, n = 8, p < 0.0001). Cetraxate maintained also tissue oxygenation without causing any significant effect on the endothelin-1-induced changes in gastric mucosal blood flow and volume. These results show that cetraxate exerts its cytoprotective action partly by maintaining mucosal oxygenation.

• Authors: S Lazaratos, H Kashimura, A Nakahara, H Fukutomi, T Osuga, T Miyauchi, K Goto
• Journal: Life sciences (Life Sci) Vol. 53 Issue 7 Pg. PL123-8 ( 1993) ISSN: 0024-3205 [Print] Netherlands
• PMID: 8350665 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Ulcer Agents
• Endothelins
• cetraxate
• Tranexamic Acid

Topics

• Animals
• Anti-Ulcer Agents (pharmacology)
• Endothelins (pharmacology)
• Gastric Mucosa (drug effects, pathology)
• Hemodynamics (drug effects)
• Male
• Rats
• Rats, Wistar
• Stomach Ulcer (chemically induced, drug therapy)
• Tranexamic Acid (analogs & derivatives, pharmacology)