Abstract | PURPOSE: To review the effects of insulin-like growth factor-1 (IGF-1) and to discuss the clinical benefits and risks of using it in patients with diabetes. DATA SOURCES: Recent publications identified through a MEDLINE search using relevant keywords. STUDY SELECTION: Selected studies on the metabolic effects and kinetic mechanisms of in vitro IGF-1 and existing literature on the effects of IGF-1 on glucose and lipid metabolism in vivo with special emphasis on data from humans. DATA SYNTHESIS: CONCLUSIONS:
Insulin-like growth factor-1 may be a useful adjunct for treatment of diabetes and may even be the drug of choice in some patients with extreme insulin resistance who have metabolic emergencies. However, further data are needed to evaluate the risks and benefits of IGF-1 use in diabetes and in other states associated with impaired insulin action.
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Authors | J W Kolaczynski, J F Caro |
Journal | Annals of internal medicine
(Ann Intern Med)
Vol. 120
Issue 1
Pg. 47-55
(Jan 01 1994)
ISSN: 0003-4819 [Print] United States |
PMID | 8250456
(Publication Type: Journal Article, Research Support, U.S. Gov't, P.H.S., Review)
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Chemical References |
- Insulin-Like Growth Factor I
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Topics |
- Animals
- Diabetes Mellitus
(drug therapy, metabolism)
- Diabetes Mellitus, Experimental
(drug therapy)
- Humans
- In Vitro Techniques
- Insulin Resistance
(physiology)
- Insulin-Like Growth Factor I
(adverse effects, pharmacokinetics, therapeutic use)
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