Production of enterotoxin, verotoxin, hemolysin and cytotoxic necrotizing factor by Escherichia coli of intestinal and extraintestinal origin.

Abstract	Seventy-six Escherichia coli strains were examined for heat-labile enterotoxin (LT), verotoxin (VT), hemolysin (HLy) and cytotoxic necrotizing factor (CNF). Thirty-six strains were isolated from patients suffering from diarrhea and forty from different extraintestinal infections. The number of LT-producing strains was low (2.6%) (one of intestinal and one of extraintestinal origin). Verotoxin was produced only by one extraintestinal strain. Four intestinal strains were hemolytic (11.2%) and also positive for CNF. From 24 hemolytic strains of extraintestinal origin (60%), 17 produced also CNF. Most of the hemolytic (30%) as well as CNF-producing strains (22.5%) were isolated from urine. Our results are similar to those of other studies confirming the close association between hemolysin and CNF production as well as a possible role of these toxic factors in pathogenesis of extraintestinal infections caused by E. coli.
Authors	A Hostacká
Journal	Folia microbiologica (Folia Microbiol (Praha)) Vol. 39 Issue 1 Pg. 79-82 ( 1994) ISSN: 0015-5632 [Print] United States
PMID	8181786 (Publication Type: Comparative Study, Journal Article)
Chemical References	Bacterial Proteins Bacterial Toxins Cytotoxins Enterotoxins Escherichia coli Proteins Hemolysin Proteins Hlya protein, E coli Shiga Toxin 1 cytotoxic necrotizing factor type 1 heat-labile enterotoxin, E coli
Topics	Adolescent Adult Aged Aged, 80 and over Bacterial Proteins (biosynthesis) Bacterial Toxins (biosynthesis) Child Child, Preschool Conjunctivitis, Bacterial (microbiology) Cytotoxins (biosynthesis) Diarrhea (microbiology) Enterotoxins (biosynthesis) Escherichia coli (isolation & purification, metabolism) Escherichia coli Infections (microbiology) Escherichia coli Proteins Hemolysin Proteins (biosynthesis) Humans Infant Infant, Newborn Intestines (microbiology) Middle Aged Organ Specificity Respiratory Tract Infections (microbiology) Shiga Toxin 1 Urinary Tract Infections (microbiology) Wound Infection (microbiology)

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