Effect of pentagastrin on gastric bicarbonate secretion in patients with duodenal ulcer & healthy controls.

Abstract

We studied the gastric acid and bicarbonate secretion rates in 12 patients with duodenal ulcer and 6 age matched healthy controls. Measurements of gastric juice volume (nonparietal and parietal), acidity and osmolality were done. The ulcer patients secreted more acid, parietal and nonparietal fluid than controls under basal conditions and after subcutaneous pentagastrin injection (6 micrograms/kg body weight). However, the gastric bicarbonate secretion was similar in the duodenal ulcer patients and controls, both under basal state as well as after pentagastrin stimulation. The gastric acidity was similar in ulcer patients and control subjects under both the states (49.3 +2- 4.5 vs 50.0 +/- 6.0 mmol/l basally, 85.2 +/- 8.9 vs 63.4 +/- 6.6 mmol/l after pentagastrin injection respectively). Thus, gastric bicarbonate secretion was similar, whereas parietal and nonparietal volume secretions were increased in patients with duodenal ulcer as compared to controls.

• Authors: K Singh, C K Nain, V Singh, B R Thapa, N K Ganguly
• Journal: The Indian journal of medical research (Indian J Med Res) Vol. 100 Pg. 122-6 (Sep 1994) ISSN: 0971-5916 [Print] India
• PMID: 7959968 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Bicarbonates
• Pentagastrin

Topics

• Adult
• Bicarbonates (metabolism)
• Duodenal Ulcer (physiopathology)
• Gastric Juice (metabolism)
• Gastric Mucosa (drug effects, metabolism)
• Humans
• Male
• Middle Aged
• Pentagastrin (pharmacology)
• Reference Values