Protective effects of papaverine salicylate in mouse ear dermatitis and PAF-induced rat paw oedema.

Abstract

Papaverine salicylate (MR-800) has been tested as a topical antiinflammatory agent in several models of skin inflammation in rodents, such as mouse ear dermatitis induced by croton oil, cantharidin or zymosan, and rat paw oedema induced by PAF. MR-800 exerted a dose-dependent inhibitory activity in all assays, when equimolar doses of sodium salicylate or papaverine were less effective, suggesting the existence of a favourable synergism between salicylate and papaverine.

• Authors: E de Bernardis, G Leonardi, A Caruso, V M Cutuli, M Amico-Roxas
• Journal: Agents and actions (Agents Actions) Vol. 42 Issue 1-2 Pg. 29-33 (Aug 1994) ISSN: 0065-4299 [Print] Switzerland
• PMID: 7847181 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Platelet Activating Factor
• papaverine salicylate
• Croton Oil
• Zymosan
• Papaverine
• Cantharidin

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (pharmacology)
• Cantharidin
• Croton Oil
• Dermatitis (pathology, prevention & control)
• Dose-Response Relationship, Drug
• Ear, External (pathology)
• Edema (chemically induced, pathology, prevention & control)
• Male
• Mice
• Papaverine (analogs & derivatives, pharmacology)
• Platelet Activating Factor
• Rats
• Rats, Sprague-Dawley
• Zymosan