Abstract | OBJECTIVES: This study was designed to compare the influence of beta- adrenergic stimulation ( dobutamine) and a selective phosphodiesterase inhibitor (MS-857) on left ventricular diastolic performance and Doppler transmitral flow velocity patterns in patients with congestive heart failure and to elucidate the mechanisms for changes in early diastolic filling induced by each agent. BACKGROUND: METHODS: RESULTS: Left ventricular filling pressure was reduced by both agents. Dobutamine decreased the time constant of isovolumetric relaxation and increased the difference between pulmonary artery wedge pressure at the peak of the v wave and left ventricular minimal pressure (10 +/- 3 to 12 +/- 4 mm Hg, p < 0.01) and peak early filling velocity (47 +/- 7 to 56 +/- 11 cm/s, p < 0.01). The diastolic pressure-volume relation showed a leftward shift in all patients. In contrast, MS-857 did not affect the time constant but maintained the pressure difference (9 +/- 3 to 8 +/- 3 mm Hg, p = NS) and peak early filling velocity (50 +/- 7 to 49 +/- 12 cm/s, p = NS). The diastolic pressure-volume relation after MS-857 showed a downward shift in most patients. CONCLUSIONS:
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Authors | K Nagata, M Iwase, T Sobue, M Yokota |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 25
Issue 2
Pg. 295-304
(Feb 1995)
ISSN: 0735-1097 [Print] United States |
PMID | 7829780
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Isoquinolines
- Phosphodiesterase Inhibitors
- Tetrahydroisoquinolines
- MS 857
- Dobutamine
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Topics |
- Administration, Oral
- Blood Flow Velocity
(drug effects)
- Cardiac Catheterization
- Coronary Circulation
(drug effects)
- Diastole
(drug effects)
- Dobutamine
(administration & dosage, pharmacology)
- Echocardiography, Doppler, Pulsed
- Female
- Heart Failure
(diagnostic imaging, physiopathology)
- Hemodynamics
(drug effects)
- Humans
- Infusions, Intravenous
- Isoquinolines
(administration & dosage, pharmacology)
- Male
- Middle Aged
- Phosphodiesterase Inhibitors
(administration & dosage, pharmacology)
- Tetrahydroisoquinolines
- Ventricular Function, Left
(drug effects)
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