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MS 857

Also Known As:

4-acetyl-1-methyl-7-(4-pyridyl)-5,6,7,8-tetrahydro-3(2H)-isoquinolinone; MS-857

Networked: 2 relevant articles (1 outcomes, 1 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Tetrahydroisoquinolines: 44
        MS 857: 2

Related Diseases

1.	Heart Failure 01/01/1988 - "Moreover, MS-857 also significantly improved the pentobarbital-induced heart failure in the heart-lung preparation. " 01/01/1988 - "Thus, MS-857 can be characterized as a potent nonsympathomimetic, nonglycoside cardiotonic drug with a selective inhibitory activity on PDE III. The cardiovascular properties revealed by this study strongly suggest that MS-857 will exert a beneficial effect in the treatment of congestive heart failure." 01/01/1988 - "In the acute heart failure models induced by either propranolol or pentobarbital, MS-857 reversed the cardiac depressant effects of these drugs. " 02/01/1995 - "Twenty patients with chronic congestive heart failure resulting from idiopathic dilated cardiomyopathy were randomized to receive intravenous infusion of dobutamine (5 micrograms/kg body weight per min, n = 10) or oral administration of MS-857 (15 mg, n = 10). "
2.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 02/01/1995 - "Twenty patients with chronic congestive heart failure resulting from idiopathic dilated cardiomyopathy were randomized to receive intravenous infusion of dobutamine (5 micrograms/kg body weight per min, n = 10) or oral administration of MS-857 (15 mg, n = 10). "
3.	Body Weight (Weight, Body) 02/01/1995 - "Twenty patients with chronic congestive heart failure resulting from idiopathic dilated cardiomyopathy were randomized to receive intravenous infusion of dobutamine (5 micrograms/kg body weight per min, n = 10) or oral administration of MS-857 (15 mg, n = 10). "

Related Drugs and Biologics

1.	Pentobarbital (Nembutal)
2.	Cardiotonic Agents (Cardiac Stimulants)
3.	Propranolol (Inderal)
4.	Dobutamine
5.	Anti-Arrhythmia Agents

Related Therapies and Procedures

1.	Intravenous Infusions
2.	Oral Administration