[Treatment of metastatic malignant insulinomas. 2 cases].

Abstract

Malignant insulinomas are slow growing tumours for which the prognosis is worsened by metastatic disease and sequellae of excess hormone secretion. Management of unresectable tumours includes intravenous chemotherapy and local treatments such as palliative surgery and transcatheter arterial embolization of liver metastases. Long-term survival can also be improved by inhibition of secretory products of the tumour with either octreotide, a somatostatin analogue, or diazoxide. We report two cases of malignant insulinomas with liver metastases for which objective responses were obtained with combination of local treatment and intravenous chemotherapy.

• Authors: L Mounedji-Boudiaf, P Rougier, S Culine, T de Baere, P Lasser, B Escudier, M Ducreux, E Kaloustian, J P Droz, A Roche
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 24 Issue 19 Pg. 894-6 (May 27 1995) ISSN: 0755-4982 [Print] France
• Vernacular Title: Traitement des insulinomes malins métastatiques. Deux observations.
• PMID: 7638129 (Publication Type: Case Reports, English Abstract, Journal Article)

Topics

• Aged
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Combined Modality Therapy
• Embolization, Therapeutic (methods)
• Humans
• Insulinoma (drug therapy, pathology, surgery)
• Liver Neoplasms (secondary, therapy)
• Male
• Middle Aged
• Pancreatic Neoplasms (drug therapy, pathology, surgery)
• Remission Induction