Effects of short-term administration of the CCK receptor antagonist, KSG-504, on regeneration of pancreatic acinar cells in acute pancreatitis in rats.

Abstract

Cholecystokinin (CCK) receptor antagonists have been reported on have an inhibitory effect on acute experimental pancreatitis, but their long-term administration is also reported to block pancreatic regeneration. We examined whether the short-term administration of KSG-504 (KSG), a synthetic CCK-A receptor antagonist, inhibited the regeneration of pancreatic acinar cells after ethionine-induced acute pancreatitis in rats. KSG (50 mg/kg), given 12 times by subcutaneous injection at 6-h intervals, prevented the reduction of protein, amylase, and trypsinogen levels, and the DNA content of the pancreas and facilitated the recovery of these values. Ornithine decarboxylase activity in pancreatic tissue and a 5-bromo-2'-deoxyuridine labeling study indicated that DNA synthesis was accelerated in rats treated with KSG. These findings suggest that the short-term administration of KSG inhibits the development of ethionine-induced acute pancreatitis and facilitates the regeneration of acinar cells.

• Authors: Y Okumura, H Inoue, Y Fujiyama, T Bamba
• Journal: Journal of gastroenterology (J Gastroenterol) Vol. 30 Issue 4 Pg. 493-9 (Aug 1995) ISSN: 0944-1174 [Print] Japan
• PMID: 7550860 (Publication Type: Journal Article)

Chemical References

• Naphthalenes
• Pentanoic Acids
• Receptors, Cholecystokinin
• KSG 504
• DNA
• Ornithine Decarboxylase
• Bromodeoxyuridine
• Ethionine

Topics

• Acute Disease
• Animals
• Bromodeoxyuridine (metabolism)
• DNA (analysis)
• Ethionine
• Male
• Naphthalenes (administration & dosage, pharmacology)
• Ornithine Decarboxylase (metabolism)
• Pancreas (metabolism, physiology)
• Pancreatitis (chemically induced, physiopathology, prevention & control)
• Pentanoic Acids (administration & dosage, pharmacology)
• Rats
• Rats, Wistar
• Receptors, Cholecystokinin (antagonists & inhibitors)
• Regeneration (drug effects)