Abstract | PURPOSE: METHODS AND MATERIALS: Forty-one patients received 53 hemibody treatments of 5-8 Gy following intravenous hydration. The patients were divided into three groups according to prehemibody irradiation treatment: Group A: no pretreatment antiemetics, 30 patients; Group B: nonondansetron antiemetics ( metoclopramide, dexamethasone, prochlorperazine), ten patients; and Group C: ondansetron, 13 patients. The incidence of radiation-induced emesis was determined prehemibody irradiation or baseline and at 1 h posthemibody irradiation in 38 patients and the results expressed as the percent change in 5-HIAA (ng/ug creatinine). RESULTS: CONCLUSION:
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Authors | C W Scarantino, R D Ornitz, L G Hoffman, R F Anderson Jr |
Journal | International journal of radiation oncology, biology, physics
(Int J Radiat Oncol Biol Phys)
Vol. 30
Issue 4
Pg. 825-30
(Nov 15 1994)
ISSN: 0360-3016 [Print] United States |
PMID | 7525517
(Publication Type: Clinical Trial, Controlled Clinical Trial, Journal Article)
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Chemical References |
- Serotonin
- Ondansetron
- Hydroxyindoleacetic Acid
- Dexamethasone
- Metoclopramide
- Prochlorperazine
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Topics |
- Dexamethasone
(therapeutic use)
- Drug Therapy, Combination
- Female
- Hemibody Irradiation
(adverse effects)
- Humans
- Hydroxyindoleacetic Acid
(urine)
- Male
- Metoclopramide
(therapeutic use)
- Ondansetron
(therapeutic use)
- Prochlorperazine
(therapeutic use)
- Radiation Injuries
(drug therapy, etiology)
- Serotonin
(physiology)
- Vomiting
(drug therapy, etiology)
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