Prochlorperazine (Compazine)

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304 relevant articles (47 outcomes, 61 trials/studies) found for this Drug

Description: A phenothiazine antipsychotic used principally in the treatment of NAUSEA; VOMITING; and VERTIGO. It is more likely than CHLORPROMAZINE to cause EXTRAPYRAMIDAL DISORDERS. (From Martindale, The Extra Pharmacopoeia, 30th ed, p612)

Also Known As:

Compazine; Prochlorperazine Edisylate; Prochlorperazine Edisylate Salt; Prochlorperazine Maleate; Edisylate Salt, Prochlorperazine; Edisylate, Prochlorperazine; Maleate, Prochlorperazine; Salt, Prochlorperazine Edisylate; 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-

Relationship Network

Drug Context: Research Results

Organic Chemicals: 40

Sulfur Compounds: 82

Phenothiazines: 415

Prochlorperazine: 304

Indoprocaf: 4

Heterocyclic Compounds: 23

3-Ring Heterocyclic Compounds

Phenothiazines: 415

Prochlorperazine: 304

Indoprocaf: 4

Experts

1.	Grazioli, Irene: 3 articles (10/2004 - 09/2002)
2.	Uslenghi, Carla: 3 articles (10/2004 - 09/2002)
3.	Grazioli, I: 2 articles (08/2007 - 10/2005)
4.	Uslenghi, C: 2 articles (08/2007 - 10/2005)
5.	Cerbo, R: 2 articles (08/2007 - 10/2005)
6.	Vinson, David R: 2 articles (08/2006 - 04/2004)
7.	Galeotti, Nicoletta: 2 articles (10/2004 - 09/2002)
8.	Ghelardini, Carla: 2 articles (10/2004 - 09/2002)
9.	Vinson, D R: 2 articles (02/2001 - 02/2001)
10.	Solorzano, Clemencia: 1 article (10/2008)

Related Diseases

1.	Vomiting 01/01/1987 - "Although prochlorperazine was less effective in offering complete protection against emesis, only 15% of the patients receiving this drug vomited more than five times" 12/01/1990 - "The median duration per episode of vomiting was also significantly greater in the prochlorperazine group than in the other two groups" 04/01/1984 - "In this study, 40 patients whose active vomiting stemmed from various causes were given 2.5 mg of prochlorperazine by slow intravenous push" 02/01/2003 - "Rescue antiemetic, prochlorperazine 12.5 mg i.m., was given if vomiting occurred more than 10 minutes after arrival in the recovery room" 03/01/2000 - "The addition of prochlorperazine might be a useful therapy for psychiatric emesis induced by anticancer agents in emotionally unstable patients." Order ALL the reference details at left...
2.	Nausea 12/01/1990 - "The median duration and severity per episode of nausea was significantly greater in the group receiving prochlorperazine alone versus the other two groups" 07/01/2006 - "An antiemetic agent, such as prochlorperazine, 5 to 10 mg orally or 25 mg by suppository, can be added on an as-needed basis every 4 to 6 hours to control nausea" 10/01/2005 - "Although fewer patients taking prochlorperazine report delayed nausea, the proportion was unacceptably high." 10/01/2005 - "Patients allocated prochlorperazine every 8 h had less delayed nausea than did those allocated 5-HT-receptor antagonists (p=0.05, t test) and those allocated prochlorperazine as needed (p=0.009, t test)" 10/01/2005 - "161 (71%) of 226 patients assigned prochlorperazine every 8 h reported delayed nausea (mean severity 3.37 [3.16-3.58]), as did 179 (79%) of 226 patients assigned 5-HT-receptor antagonists (3.29 [3.09-3.48]) and 179 (82%) of 219 patients assigned prochlorperazine as needed (3.33 [3.15-3.50]); groups did not differ in mean severity (p=0.853, one-way ANOVA)" Order ALL the reference details at left...
3.	Migraine Disorders (Migraine) 08/01/1994 - "STUDY OBJECTIVE: To assess the safety and efficacy of rectal prochlorperazine in the treatment of acute migraines" 08/01/1994 - "Safety and efficacy of rectal prochlorperazine for the treatment of migraine in the emergency department." 10/01/2002 - "OBJECTIVES: To study the efficacy and tolerability of prochlorperazine (PCZ) management of acute migraine" 04/01/2001 - "OBJECTIVE: To study the effectiveness of prochlorperazine in aborting severe, intractable migraines in children" 04/01/2001 - "The effectiveness of intravenous prochlorperazine in 20 consecutive patients referred to the emergency department for severe, prolonged migraines was retrospectively reviewed" Order ALL the reference details at left...
4.	Headache (Headaches) 04/01/2000 - "The objective of this study was to determine the efficacy of MgSO(4) vs. prochlorperazine in emergency department (ED) patients with acute headache" 02/24/1989 - "Randomized double-blind trial of intravenous prochlorperazine for the treatment of acute headache." 10/01/2000 - "After intravenous prochlorperazine treatment, 121 (90%) achieved a 50% or greater reduction of headache intensity, including 85 (63%) who became headache-free" 03/01/1992 - "High prochlorperazine doses (10 mg.) aborted the most headaches (95%) in the shortest time, but caused more sedation and akathesia" 07/28/1989 - "Intravenous prochlorperazine for acute headache." Order ALL the reference details at left...
5.	Postoperative Nausea and Vomiting (PONV) 11/01/1993 - "This study demonstrates that prochlorperazine at the dose used is effective in preventing postoperative nausea in the patient population studied." 10/01/1996 - "prochlorperazine reduced the severity of postoperative vomiting" 09/01/1989 - "The effectiveness of 10 mg IV prochlorperazine in preventing postoperative nausea and vomiting was compared with placebo when given perioperatively to 100 patients in a prospective double-blind randomized trial" 09/01/1996 - "The frequency of those experiencing no PONV was increased from 27% (placebo) by prochlorperazine i.m" 04/01/1990 - "The incidence of postoperative emesis was 11/25 (44%) in group 1, 3/25 (12%, p less than 0.05) in group 2, 9/25 (36%) in group 3, and 3/25 (12%, p less than 0.05) in group 4. Our results suggest that electro-acupuncture is as effective as prochlorperazine, and may be better than transcutaneous electrical nerve stimulation, in reducing postoperative emesis." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Cisplatin (Platino)
2.	Metoclopramide (Reglan)
3.	Ondansetron (Zofran)
4.	Dexamethasone (Maxidex)
5.	Indomethacin (Indometacin)
6.	Caffeine (No Doz)
7.	Droperidol
8.	Granisetron (Kytril)
9.	Sumatriptan (Imigran)
10.	Indoprocaf

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Knee Replacement Arthroplasty (Total Knee Replacement)
3.	Hip Replacement Arthroplasty (Total Hip Replacement)
4.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
5.	Transcutaneous Electric Nerve Stimulation (TENS)

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