[The biological activity of saparal in an influenzal infection].

Abstract

The antiviral and interferon-inducing activity of saparal, an adaptogen of plant origin, was studied. Tests in experimental mice demonstrated the interferon-inducing activity of saparal providing its antiviral effect. An optimal scheme of saparal administration was developed. The preparation had no direct inhibitory effect on influenza virus replication. The application of saparal for prophylaxis among workers resulted in a 2-fold or greater decrease of influenza and other ARD morbidity and in an increase of endogenous serum interferon level in 67-75% of the persons examined.

• Authors: M S Paramonova, V M Gagarinova, M A Rodina, V M Guseva, V V Burmistrova, Z A Osipova, O A Aksenov
• Journal: Voprosy virusologii (Vopr Virusol) 1994 May-Jun Vol. 39 Issue 3 Pg. 131-4 ISSN: 0507-4088 [Print] Russia (Federation)
• Vernacular Title: Biologicheskaia aktivnost' saparala pri grippoznoĭ infektsii.
• PMID: 7522378 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Antiviral Agents
• Interferon Inducers
• Plant Extracts
• saparal
• Interferons

Topics

• Animals
• Antiviral Agents (therapeutic use)
• Cells, Cultured
• Chick Embryo
• Drug Evaluation
• Drug Evaluation, Preclinical
• Humans
• Influenza A virus (drug effects)
• Influenza, Human (blood, drug therapy, epidemiology, prevention & control)
• Interferon Inducers (therapeutic use)
• Interferons (blood, drug effects)
• Mice
• Plant Extracts (therapeutic use)
• Russia (epidemiology)
• Seasons