Abstract |
Improved leukemia therapies in children have brought about prolonged remissions with extramedullary relapses being reported in sites other than the most common (bone marrow, testes, brain, and spinal cord). A 3-1/2 year-old boy with a history of acute lymphocytic leukemia presented with total retinal detachment in one eye. Painful glaucoma unresponsive to medical therapy necessitated enucleation. Histopathologic examination documented the presence of a dense leukemic cellular infiltrate replacing a totally detached, necrotic retina. Tumor cells also were present in the optic nerve. The child had remained free of leukemia for 3 years after systemic and intrathecal chemotherapy, supplemented by craniospinal radiation. This represents the first case of relapse of acute lymphocytic leukemia presenting solely as a retinal detachment. Our case also underscores the point that the treatment of leukemia after an isolated ocular relapse can be associated with a favorable outcome.
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Authors | J D Primack, M E Smith, L Tychsen |
Journal | Journal of pediatric ophthalmology and strabismus
(J Pediatr Ophthalmol Strabismus)
1995 Jul-Aug
Vol. 32
Issue 4
Pg. 253-6
ISSN: 0191-3913 [Print] United States |
PMID | 7494164
(Publication Type: Case Reports, Journal Article)
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Topics |
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Child, Preschool
- Eye Enucleation
- Follow-Up Studies
- Glaucoma
(etiology)
- Humans
- Injections, Spinal
- Leukemic Infiltration
(pathology)
- Magnetic Resonance Imaging
- Male
- Optic Nerve
(pathology)
- Pain
(etiology)
- Precursor Cell Lymphoblastic Leukemia-Lymphoma
(complications, diagnosis, therapy)
- Radiotherapy, Adjuvant
- Recurrence
- Retina
(pathology)
- Retinal Detachment
(diagnosis, etiology, therapy)
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