[Effect of carminomycin on the structural integrity, primary susceptibility to radiation damage and the postradiation repair of the cellular DNA-membrane complex in Ehrlich's ascitic carcinoma].

Abstract

It was found with the method of sedimentation analysis in sucrose alkaline gradients that carminomycin induced in vivo degradation of the DNA-membrane complex of the Ehrlich's ascites carcinoma cells (EAC). The concentration dependence of the complex damage correlated well with the data on the cell survival: the subtoxic concentration of the antibiotic according to these tests was 0.001 micrograms/ml. Combined effect of carminomycin in the subtoxic concentration and gamma-radiation on the cells did not result in any increase in the primary radiation damage to the DNA-membrane complex. Still, it inhibited its post-radiation reparation. This suggested that on the combined use of the above damaging agents the antibiotic significantly increased the effect of the ionizing radiation on the cells.

• Authors: V I Paranosenkova, A S Saenko
• Journal: Antibiotiki (Antibiotiki) Vol. 26 Issue 4 Pg. 306-10 (Apr 1981) ISSN: 0003-5637 [Print] Russia (Federation)
• Vernacular Title: Deĭstvie karminomitsina na strukturnuiu tselostnost', pervichnuiu radioporazhaemost' i postradiatsionnuiu reparatsiiu DNK-membrannogo kompleksa kletok astsitnoĭ kartsinomy Erlikha.
• PMID: 7235672 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm
• Carubicin
• Daunorubicin

Topics

• Animals
• Carcinoma, Ehrlich Tumor (drug therapy)
• Carubicin (therapeutic use)
• Cell Membrane (drug effects, radiation effects)
• Cells, Cultured
• DNA Repair (radiation effects)
• DNA, Neoplasm (radiation effects)
• Daunorubicin (analogs & derivatives)
• Gamma Rays
• Mice
• Neoplasm Transplantation