Clonal origin and trisomy of chromosome 15 in murine B-cell malignancies.

Abstract

During the course of a multifaceted study of clonality in murine neoplasms we observed two B-lymphoid malignancies. Results of studies with the X-chromosome-linked enzyme phosphoglycerate kinase strongly suggest that these tumors had a clonal origin. Each of them had trisomy 15. This chromosomal abnormality has been found consistently in many murine thymic neoplasms, and has been thought to be specific to tumors of thymic origin. However, the occurrence of trisomy 15 in each of the only two B-cell malignancies thus far detected in our studies indicates that it may occur in B-lymphoid progenitors as well.

• Authors: P J Fialkow, A L Reddy, J I Bryant
• Journal: International journal of cancer (Int J Cancer) Vol. 26 Issue 5 Pg. 603-8 (Nov 15 1980) ISSN: 0020-7136 [Print] United States
• PMID: 6972357 (Publication Type: Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Phosphoglycerate Kinase

Topics

• Animals
• B-Lymphocytes (immunology)
• Female
• Leukemia, Experimental (genetics, immunology)
• Lymphoma (genetics, immunology)
• Mice
• Neoplasms, Experimental (genetics, immunology)
• Phosphoglycerate Kinase (analysis)
• Trisomy