Histologic study of pulp capping in rat molars using calcitonin.

Abstract

Calcitonin, a calcium regulating hormone, has been found to affect bone formation and resorption. In this study a calcitonin preparation and a calcium hydroxide preparation for comparison were applied to both exposed and unexposed rat molar pulps. Histologic examinations were conducted after periods of 1 day to 28 days. Calcium hydroxide pulp caps produced varying amounts of secondary dentin and inflammation. Calcitonin applied as an indirect agent had a similar effect. When calcitonin was applied to exposed pulp, a large amount of dense fibrous connective tissue reminiscent of scar tissue was formed. With increased time this connective tissue exhibited signs of progressive, orderly calcification continuing through a large portion of the coronal pulp.

• Authors: H S Smith, N N Soni
• Journal: Oral surgery, oral medicine, and oral pathology (Oral Surg Oral Med Oral Pathol) Vol. 53 Issue 3 Pg. 311-7 (Mar 1982) ISSN: 0030-4220 [Print] United States
• PMID: 6950347 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Calcitonin
• Calcium Hydroxide

Topics

• Animals
• Calcitonin (pharmacology)
• Calcium Hydroxide (pharmacology)
• Dental Pulp (drug effects)
• Dental Pulp Capping
• Dentin, Secondary (chemically induced)
• Molar (drug effects)
• Rats
• Rats, Inbred Strains
• Time Factors