Thyroxine-binding globulin capacity and concentration evaluated from blood spots on filter-paper in a screening program for neonatal hypothyroidism.

Abstract

We describe a simple method for evaluating thyroxine-binding globulin capacity and concentration from a single 1-cm blood spot on filter-paper used in a screening program for neonatal hypothyroidism. This method permits prompt diagnosis of about 90% of the infants with thyroxine-binding globulin deficiency in our abnormal low-thyroxine, low-thyrotropin population. There was excellent equivalence between results obtained by our method and by the method of Chopra et al. (J. Clin. Endocrinol. Metab. 35:565, 1972), and minimal overlap between the population with low thyroxine-binding globulin and the low-thyroxine, normal thyrotropin population. We recommend this method to all programs in which a primary thyroxine measurement is used in screening for congenital hypothyroidism.

• Authors: J H Dussault, J Morissette, J Letarte, H Guyda, C Laberge
• Journal: Clinical chemistry (Clin Chem) Vol. 26 Issue 3 Pg. 463-5 (Mar 1980) ISSN: 0009-9147 [Print] England
• PMID: 6767570 (Publication Type: Journal Article)

Chemical References

• Thyroxine-Binding Proteins
• Charcoal
• Thyrotropin
• Thyroxine

Topics

• Blood Specimen Collection
• Charcoal
• Congenital Hypothyroidism
• Humans
• Hypothyroidism (diagnosis)
• Infant, Newborn
• Mass Screening
• Paper
• Reference Values
• Thyrotropin (blood)
• Thyroxine (blood)
• Thyroxine-Binding Proteins (analysis)