Immunopharmacological profile of TEI-3096: a new immunomodulator.

Abstract

TEI-3096 [6-p-chlorobenzyl-5H-2,3,6,7-terahydro-5,7-dioxothiazolo (3,2-a) pyrimidine], a novel thiazolopyrimidine compound has been shown to suppress adjuvant arthritis in rats without any effect on conventional inflammation. We examined the immuno-pharmacological profile of TEI-3096 in murine lymphocytes. The blastformation induced by Con A or LPS was inhibited by addition of 50-500 microM concentrations of TEI-3096. This compound suppressed elevated plaque-forming cell (PFC) response against T cell-dependent antigen. However, TEI-3096 had no effect either on normal PFC response or on antibody formation against T cell independent antigen. Although orally administered TEI-3096 had no obvious effect on anti-SRBC PFC response in normal mice, it normalized the colchicine-induced enhancement of antibody formation against TNP-HGG. TEI-3096 also enhanced the delayed type hypersensitivity in mice and rats. These results suggests that TEI-3096 restores the abnormal immune response. Therefore, it may be useful for the treatment of auto-immune disease such as rheumatoid arthritis.

• Authors: K Komoriya, M Tsuchimoto, T Naruchi, T Okimura, I Yamamoto
• Journal: Journal of immunopharmacology (J Immunopharmacol) 1982-1983 Vol. 4 Issue 4 Pg. 285-301 ISSN: 0163-0571 [Print] United States
• PMID: 6764224 (Publication Type: Journal Article)

Chemical References

• Adjuvants, Immunologic
• Thiazoles
• TEI 3096
• Colchicine
• Thymidine

Topics

• Adjuvants, Immunologic (pharmacology)
• Animals
• Arthritis, Experimental (drug therapy)
• Colchicine (pharmacology)
• Female
• Hemolytic Plaque Technique
• Hypersensitivity, Delayed
• In Vitro Techniques
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred C3H
• Rats
• Rats, Inbred Strains
• Spleen (metabolism)
• Thiazoles (pharmacology)
• Thymidine (metabolism)