Pharmacological study of the antitussive and respiratory-analeptic properties of N-(2'-ethylpyrrolidino)diphenylacetamide hydrochloride (F 1459).

Abstract

The antitussive and respiratory stimulant properties of N-(2'-ethylpyrrolidino)diphenylacetamide hydrochloride (F 1459) in animals are reported. In the mechanical stimulation of the trachea in guinea pigs and after intraperitoneal administration of the product, F 1459 showed a better antitussive action as compared to oxeladin, zipeprol, codeine and clobutinol. Low intraduodenal doses of F 1459 also reduced in cats the cough induced by the electrical stimulation of the superior laryngeal nerve. In anesthetized dogs whose respiratory functions had been depressed by morphine, F 1459 significantly increased the volume inspired per minute, an effect not due to any uncoupling effect on oxidative phosphorylation. F 1459 has local anesthetic and broncholytic properties that may play a role in the mechanism of its antitussive action. Contrarily to codeine, the test compound did not induce a decrease in the intestinal transit.

• Authors: J P Tarayre, P Vilain, H Lauressergues, J Cauquil, M Bru, V Caillol, G Pouget, A M Jougla, M Go
• Journal: Arzneimittel-Forschung (Arzneimittelforschung) Vol. 33 Issue 7 Pg. 931-5 ( 1983) ISSN: 0004-4172 [Print] Germany
• PMID: 6684929 (Publication Type: Journal Article)

Chemical References

• Anesthetics, Local
• Antitussive Agents
• Lactates
• Pyrrolidines
• Lactic Acid
• F 1459
• Morphine

Topics

• Anesthetics, Local
• Animals
• Antitussive Agents
• Blood Gas Analysis
• Cats
• Dogs
• Drug Interactions
• Electric Stimulation
• Female
• Guinea Pigs
• Hemodynamics (drug effects)
• In Vitro Techniques
• Lactates (blood)
• Lactic Acid
• Laryngeal Nerves (physiology)
• Male
• Mice
• Morphine (pharmacology)
• Pyrrolidines (pharmacology)
• Respiration (drug effects)
• Stimulation, Chemical
• Trachea (drug effects)