Duodenal somatostatinoma. Immunohistopathology and review of literature.

Abstract

A case of duodenal somatostatinoma is reported. The patient, a 54-year-old male, had complained of an epigastric pain due to gastric ulcer and a duodenal polyp was unexpectedly found at a gastrectomy. The polyp showed basically tubular adenocarcinoma, with negative argyrophil and argentaffin reactions. By an indirect immunofluorescent examination almost all of the tumor cells were revealed as somatostatin-immunoreactive. Big somatostatin was also positive. Radioimmunoassay of the tumor indicated 6400 pg of somatostatin-like immunoreactivity per milligram of wet tissue. This seems to be the second case of duodenal somatostatinoma, following the case reported by us previously.

• Authors: H Kaneko, M Toshima, H Kobayashi, M Kitazawa, S Ito, T Iwanaga, Y Kusumoto, T Fujita, H Nitta
• Journal: Acta pathologica japonica (Acta Pathol Jpn) Vol. 33 Issue 1 Pg. 153-8 (Jan 1983) ISSN: 0001-6632 [Print] Australia
• PMID: 6301208 (Publication Type: Case Reports, Journal Article)

Topics

• Adenoma, Islet Cell (immunology)
• Duodenal Neoplasms (immunology, surgery, ultrastructure)
• Fluorescent Antibody Technique
• Humans
• Immunoassay
• Intestinal Polyps (immunology, surgery)
• Male
• Middle Aged
• Pancreatectomy
• Somatostatinoma (immunology, surgery, ultrastructure)