Anti-anaphylactic activities of a new benzopyranopyridine derivative Y-12,141 in rats and guinea pigs.

Abstract

The active anaphylactic bronchoconstriction of rats mediated by IgE-like antibody against DNP-Ascaris was inhibited by intravenous and intratracheal treatment with Y-12,141 in a dose-dependent manner. In both routes, the inhibitory effect of Y-12,141 on this response was more potent than that of disodium cromoglycate (DSCG). The oral administration of Y-12,141 also produced a similar inhibition of the response. The passive anaphylactic bronchoconstriction of guinea pigs mediated by IgG-like antibody against egg albumin was also prevented dose-dependently by treatment with Y-12,141 given intravenously, but not with DSCG. The present results suggest that Y-12,141 may be effective for the treatment of allergic bronchial asthma.

• Authors: K Goto, M Terasawa, Y Kadobe, Y Maruyama
• Journal: Japanese journal of pharmacology (Jpn J Pharmacol) Vol. 30 Issue 4 Pg. 537-47 (Aug 1980) ISSN: 0021-5198 [Print] Japan
• PMID: 6162988 (Publication Type: Journal Article)

Chemical References

• Azoles
• Chromones
• SRS-A
• Tetrazoles
• traxanox
• Cromolyn Sodium

Topics

• Anaphylaxis (drug therapy)
• Animals
• Asthma (drug therapy)
• Azoles (therapeutic use)
• Chromones (administration & dosage, therapeutic use)
• Cromolyn Sodium (administration & dosage, therapeutic use)
• Disease Models, Animal
• Dose-Response Relationship, Drug
• Guinea Pigs
• Histamine Release
• Lung (immunology)
• Male
• Rabbits
• Rats
• SRS-A (metabolism)
• Tetrazoles (administration & dosage, therapeutic use)