[Free radical mechanism of action of pyrimido-triazine antibiotics].

Abstract

EPR spectra of anion radicals were recorded as a result of chemical or enzymatic reduction at various pH of the pyrimido-triazine antibiotics. These anion radicals easily form superoxide radicals in the presence of oxygen. It is supposed that a higher selectivity of reumycin action is due to difference in the redox potentials of the neutral and ionized antibiotic forms. A possibility of enhance the reumycin potency may involve the pH lowering inside the tumor cells - for example, by glucose injections.

• Authors: V S Orlov, G N Bogdanov, N M Emanuél', S E Esipov, S M Navashin
• Journal: Bioorganicheskaia khimiia (Bioorg Khim) Vol. 9 Issue 4 Pg. 556-60 (Apr 1983) ISSN: 0132-3423 [Print] Russia (Federation)
• Vernacular Title: Svobodnoradikal'nye mekhanizmy deĭstviia pirimidotriazinovykh antibiotikov.
• PMID: 6091693 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antibiotics, Antineoplastic
• Free Radicals
• Triazines
• Epinephrine

Topics

• Animals
• Antibiotics, Antineoplastic (metabolism, pharmacology)
• Electron Spin Resonance Spectroscopy
• Epinephrine (metabolism)
• Free Radicals
• In Vitro Techniques
• Microsomes, Liver (metabolism)
• Oxidation-Reduction
• Rats
• Triazines (metabolism, pharmacology)