Pharmacology of cis(Z)-clopenthixol decanoate, a depot neuroleptic.

Abstract

The duration and intensity of the neuroleptic effect of cis(Z)-clopenthixol decanoate in Viscoleo have been compared with those of cis(Z)-clopenthixol, 2 HCl in aqueous solution in a number of animal experimental models. Cis(Z)-clopenthixol, 2 HCl had a strong, but short-lasting neuroleptic effect (apomorphine antagonistic effect in dogs, inhibition of conditioned avoidance response in rats) which was accompanied by marked sedation. In contrast, cis(Z)-clopenthixol decanoate in oil had an effect which was slower in onset, but of much longer duration and only the highest doses caused a slight sedation. In rats catalepsy could be induced in some animals by high doses of cis(Z)-clopenthixol decanoate whereas cis(Z)-clopenthixol, 2 HCl at all the doses tested caused catalepsy in all animals. In mice only high doses of cis(Z)-clopenthixol decanoate in oil caused reduction of spontaneous motor activity and potentiation of barbiturate anaesthesia. The results are discussed with special reference to the clinical use of the depot preparation.

• Authors: V Pedersen, O Svendsen, P Danneskiold-Samsoe, V Boeck, I M Nielsen
• Journal: Acta pharmacologica et toxicologica (Acta Pharmacol Toxicol (Copenh)) Vol. 40 Issue 4 Pg. 482-90 (Apr 1977) ISSN: 0001-6683 [Print] Denmark
• PMID: 577108 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Barbiturates
• Delayed-Action Preparations
• Thioxanthenes
• Clopenthixol
• Apomorphine

Topics

• Administration, Oral
• Animals
• Apomorphine (antagonists & inhibitors, pharmacology)
• Barbiturates (pharmacology)
• Behavior, Animal (drug effects)
• Catalepsy
• Clopenthixol (administration & dosage, antagonists & inhibitors, pharmacology)
• Delayed-Action Preparations
• Dogs
• Dose-Response Relationship, Drug
• Drug Evaluation, Preclinical
• Drug Synergism
• Escape Reaction (drug effects)
• Female
• Humans
• Injections, Subcutaneous
• Male
• Mice
• Motor Activity (drug effects)
• Rats
• Thioxanthenes (administration & dosage)
• Time Factors