Effects of chronic changes in hemoglobin-O2 affinity in rats.

Abstract

We have assessed the characteristics of oxygen transport following chronic intraperitoneal administration of sodium cyanate (NaCNO, 90 mg/kg; P50 decreased), o-iodosodium benzoate (OISB, 300 mg/kg; P50 increased), or sodium chloride (NaCl; P50 unchanged) to rats at a rate of 5 times/wk for 16 wk. At the end of this period, the animals were exposed to a low inspired O2 concentration and were subjected to exercise stress. Hill's n50 at pH 6.90-7.60, hematocrit, and the saturation dependency of the Bohr effect (PCO2 constant) were altered by NaCNO only. Cyanate-treated rats gained less weight, probably due to a toxic side effect of the drug. Hypoxemia-induced lactatemia was greatest with a high P50 (OISB). Physical effort (swimming) was tolerated poorly at normal arterial PO2 when P50 was low (NaCNO). Although a left-shifted curve appears beneficial when FIO2 is reduced, reasons for the physiological advantage may be the result of other characteristics of the O2 dissociation curve, not P50 alone.

• Authors: B P Teisseire, C D Soulard, R A Hérigault, L F Leclerc, M B Laver
• Journal: Journal of applied physiology: respiratory, environmental and exercise physiology (J Appl Physiol Respir Environ Exerc Physiol) Vol. 46 Issue 4 Pg. 816-22 (Apr 1979) ISSN: 0161-7567 [Print] United States
• PMID: 457561 (Publication Type: Journal Article)

Chemical References

• Benzoates
• Cyanates
• Hemoglobins
• Sodium Chloride
• Oxygen

Topics

• Animals
• Benzoates (pharmacology)
• Cyanates (pharmacology)
• Hemoglobins (metabolism)
• Mathematics
• Oxygen (blood)
• Rats
• Sodium Chloride (pharmacology)
• Stress, Physiological (physiopathology)
• Time Factors