Effect of promethazine and isosafrole on rat-hepatic microsomal mono-oxygenase activity: comparison with classic inducers phenobarbitone and beta-naphthoflavone.

Abstract

The characteristics of induction of rat-hepatic microsomal mono-oxygenase activity by promethazine and isosafrole have been investigated and compared with the classic inducers phenobarbitone and beta-naphthoflavone. Both promethazine and isosafrole pretreatments result in increased cytochromes P-450, and enhanced NADPH-cytochrome c reductase, aminopyrine N-demethylase, dichloronitroanisole O-demethylase, ethoxycoumarin O-deethylase and ethoxyresorufin O-deethylase activity. Isosafrole but not promethazine increased the liver to body weight ratio. It is concluded that promethazine and isosafrole pretreatment produces an induction of the rat-hepatic microsomal mono-oxygenase system which shows both phenobarbitone- and polycyclic aromatic hydrocarbon-type characteristics.

• Authors: G Taylor, J B Houston, C R Elcombe
• Journal: Xenobiotica; the fate of foreign compounds in biological systems (Xenobiotica) Vol. 15 Issue 3 Pg. 243-9 (Mar 1985) ISSN: 0049-8254 [Print] England
• PMID: 4024659 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Benzoflavones
• Dioxoles
• Flavonoids
• beta-Naphthoflavone
• Oxygenases
• Promethazine
• Safrole
• isosafrole
• Phenobarbital

Topics

• Animals
• Benzoflavones (pharmacology)
• Body Weight (drug effects)
• Dioxoles (pharmacology)
• Enzyme Induction
• Flavonoids (pharmacology)
• Male
• Microsomes, Liver (enzymology)
• Organ Size (drug effects)
• Oxygenases (biosynthesis)
• Phenobarbital (pharmacology)
• Promethazine (pharmacology)
• Rats
• Rats, Inbred Strains
• Safrole (pharmacology)
• beta-Naphthoflavone