Pubertas praecox and hypothalamic hamartoma.

Abstract

Precocious puberty of cerebral origin is classified into pseudoprecocious puberty and true precocious puberty. Pseudoprecocious puberty is caused by HCG secreting tumours. True precocious puberty is caused by various hypothalamic diseases. Among them, hypothalamic hamartoma is the most common cause. Precocious puberty is caused by elevated blood pituitary gonadotropin concentration, secondary to the elevated hypothalamic LHRH secretion. The hypothalamic hamartoma is not infrequently associated with laughing (gelastic) seizures as well as convulsions. Diagnosis of a hypothalamic hamartoma is easily made by CT. Although the hypothalamic hamartoma is difficult to operate on, the value of surgery is stressed for treatment of precocious puberty. This is also confirmed by recent reports.

• Authors: J Takeuchi, H Handa
• Journal: Neurosurgical review (Neurosurg Rev) Vol. 8 Issue 3-4 Pg. 225-31 ( 1985) ISSN: 0344-5607 [Print] Germany
• PMID: 3897897 (Publication Type: Journal Article)

Chemical References

• Chorionic Gonadotropin
• Gonadotropin-Releasing Hormone

Topics

• Child
• Chorionic Gonadotropin (blood)
• Female
• Gonadotropin-Releasing Hormone (metabolism)
• Hamartoma (complications, diagnosis, metabolism, surgery)
• Humans
• Hypothalamic Neoplasms (complications, diagnosis, metabolism, surgery)
• Laughter
• Male
• Puberty, Precocious (etiology)
• Seizures (etiology)
• Tomography, X-Ray Computed