[Extracorporeal support treatment in severe malaria].

Abstract

Malaria is a wide-spread disease in tropical areas. The severe form is characterized by organic involvement and/or hyperparasitaemia. Criteria for early monitoring in intensive care rooms are defined; without a timely and early treatment, severe malaria has a 100% mortality. Although the literature in these cases is not extensive, extracorporeal therapy used sequentially for hepatic and renal detoxification is a useful and safe tool that can be used in intensive care. We describe the case of a 36-year-old man with a diagnosis of severe malaria according to WHO criteria. He began treatment with intravenous artesunate and due to a torpid evolution, a sudden increase in bilirubinemia with encephalopathy, parameters of acute kidney injury and acute pulmonary edema, undergoes extracorporeal sequential treatment, coupled with plasma filtration adsorption, high-exchange plasmapheresis, and continuous hemodiafiltration with favorable evolution. This case shows that extracorporeal support in trained hands and in a timely manner is effective when organ failure evolves rapidly to achieve stability and provide necessary time for definitive treatment, in this case rapid action antimalarials until parasitemia becomes negative.

• Authors: Rosana Gregori Sabelli, Yesica Lamberto, Pablo Saul, Natalia Campagnucci, Viviana Chediack, Eleonora Cunto
• Journal: Medicina (Medicina (B Aires)) Vol. 83 Issue 5 Pg. 828-831 ( 2023) ISSN: 1669-9106 [Electronic] Argentina
• Vernacular Title: Tratamiento con sostén extracorpóreo en malaria grave.
• PMID: 37870345 (Publication Type: Case Reports, English Abstract)

Chemical References

• Antimalarials
• Artesunate

Topics

• Male
• Humans
• Adult
• Malaria, Falciparum (diagnosis, drug therapy)
• Malaria (drug therapy)
• Antimalarials (therapeutic use)
• Artesunate (therapeutic use)
• Brain Diseases (drug therapy)