Abstract | OBJECTIVES: METHODS: A total of eighty-eight patients in China who had been diagnosed with JDM and subjected to tofacitinib therapy for over 3 months were retrospectively analyzed. Skin and muscle manifestations were assessed using the Cutaneous Assessment Tool-binary method (CAT-BM), Childhood Myositis Assessment Scale (CMAS), and kinase. Pulmonary function was assessed using a high-resolution CT (computerized tomography) scan and pulmonary symptoms. All patients were subjected to regular follow-up, and core measures were assessed every 3 months after initiation. Furthermore, the data were analyzed using the Wilcoxon single test, Mann-Whitney U test, and chi-square test. RESULTS: Compared with the baseline data, skin and muscle manifestations were found significantly improved during the respective follow-up visit. At the most recent follow-up, nearly 50% of patients achieved a clinical complete response and six patients received tofacitinib monotherapy. Sixty percent of patients suffering from interstitial lung disease well recovered on high-resolution CT. Seventy-five percent of patients showed a reduction in the size or number of calcinosis, and 25% of patients showed completely resolved calcinosis. CONCLUSION:
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Authors | Junmei Zhang, Li Sun, XinWei Shi, Shipeng Li, Cuihua Liu, Xiaoqing Li, Meiping Lu, Jianghong Deng, Xiaohua Tan, Wanzhen Guan, Guomin Li, Xinran Wen, Ping Liu, Caifeng Li |
Journal | Arthritis research & therapy
(Arthritis Res Ther)
Vol. 25
Issue 1
Pg. 204
(10 18 2023)
ISSN: 1478-6362 [Electronic] England |
PMID | 37853451
(Publication Type: Journal Article)
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Copyright | © 2023. BioMed Central Ltd., part of Springer Nature. |
Chemical References |
- Janus Kinase Inhibitors
- tofacitinib
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Topics |
- Humans
- Child
- Dermatomyositis
(diagnosis)
- Retrospective Studies
- Janus Kinase Inhibitors
(therapeutic use)
- Lung Diseases, Interstitial
(diagnostic imaging, drug therapy)
- Calcinosis
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