Abstract | BACKGROUND:
Esophageal stricture is a major complication after esophageal endoscopic submucosal dissection (ESD) and when the mucosal defect exceeds 3/4 of the circumference. Various preventive methods have been reported to prevent stenosis. However, in the case of circumferential ESD, there is no way to prevent luminal stenosis effectively. This retrospective study aimed to evaluate the efficacy of 20-French nasogastric tubes (NGT) combined with oral steroids for the prevention of esophageal stricture after endoscopic submucosal dissection. METHODS: Between January 2012 and December 2021, we enrolled 57 patients with post-ESD mucosal defects exceeding 3/4 of the esophageal circumference. Of them, the initial seven patients received oral steroid therapy and the subsequent 50 patients received 20-French NGT placements combined with oral steroid therapy. We retrospectively evaluated the rates of strictures and refractory strictures and explored risk factors for strictures with 20-French NGT. RESULTS: CONCLUSION: Using a 20-French NGT placement combined with oral steroid administration is an easy and safe alternative to prevent esophageal stricture after ESD, especially for patients with noncircumferential mucosal defects. Further studies are needed to develop an effective stricture prevention method for post-ESD whole-circumferential mucosal defects of the esophagus.
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Authors | Jing Wang, Weifeng Li, Yan Yan, Peng Yuan, Changqi Cao, Shijie Li, Qi Wu |
Journal | Surgical endoscopy
(Surg Endosc)
Vol. 37
Issue 11
Pg. 8892-8900
(Nov 2023)
ISSN: 1432-2218 [Electronic] Germany |
PMID | 37816996
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
Chemical References |
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Topics |
- Humans
- Esophageal Stenosis
(etiology, prevention & control)
- Constriction, Pathologic
(etiology)
- Endoscopic Mucosal Resection
(adverse effects, methods)
- Retrospective Studies
- Esophageal Neoplasms
(pathology)
- Carcinoma, Squamous Cell
(surgery)
- Steroids
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