Vitamin C, a potent reducing and
antioxidant agent, plays an important role in the body, aiding in the growth of cartilage and bones. It is also involved in mechanisms that help reduce
inflammation and its effects on the body. In addition,
vitamin C decreases pro-inflammatory
cytokines, such as
IL-6, which produce
acute-phase proteins such as CRP and influence inflammatory markers such as ESR. We carried out a study with 110 patients who underwent
total knee replacement surgery. We divided the patients into two groups, in which the intervention group received 15 g of parenteral
vitamin C during the immediate postoperative period while the control group did not. Patients who received 15 g of
vitamin C after
total knee replacement surgery had decreased inflammatory markers, specifically CRP and ESR. Overall, administering
vitamin C in the post-surgical period results in improved management of
inflammation, as evidenced by a decrease in CRP and ESR values. This leads to faster recovery and better healing outcomes for patients undergoing
total knee replacement surgery. Furthermore, the beneficial effects of
vitamin C in reducing proinflammatory
cytokines, reducing the need for
opioid analgesics, and its mild adverse effects make it a promising adjuvant in managing postoperative recovery.