Recent Advances in the Development of Pyrazole Derivatives as Anticancer Agents.

Abstract

Pyrazole derivatives, as a class of heterocyclic compounds, possess unique chemical structures that confer them with a broad spectrum of pharmacological activities. They have been extensively explored for designing potent and selective anticancer agents. In recent years, numerous pyrazole derivatives have been synthesized and evaluated for their anticancer potential against various cancer cell lines. Structure-activity relationship studies have shown that appropriate substitution on different positions of the pyrazole ring can significantly enhance anticancer efficacy and tumor selectivity. It is noteworthy that many pyrazole derivatives have demonstrated multiple mechanisms of anticancer action by interacting with various targets including tubulin, EGFR, CDK, BTK, and DNA. Therefore, this review summarizes the current understanding on the structural features of pyrazole derivatives and their structure-activity relationships with different targets, aiming to facilitate the development of potential pyrazole-based anticancer drugs. We focus on the latest research advances in anticancer activities of pyrazole compounds reported from 2018 to present.

• Authors: Yingqian Zhang, Chenyuan Wu, Nana Zhang, Rui Fan, Yang Ye, Jun Xu
• Journal: International journal of molecular sciences (Int J Mol Sci) Vol. 24 Issue 16 (Aug 12 2023) ISSN: 1422-0067 [Electronic] Switzerland
• PMID: 37628906 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents
• Pyrazoles
• Tubulin

Topics

• Antineoplastic Agents (pharmacology)
• Pyrazoles (pharmacology)
• Cell Line
• Structure-Activity Relationship
• Tubulin