Total Pancreatectomy with Islet Auto-Transplantation: Surgical Procedure, Outcomes, and Quality of Life.

Abstract

Chronic pancreatitis is a progressive and irreversible process of pancreatic inflammation and fibrosis that can lead to intractable abdominal pain and severely impaired quality of life (QoL). Often patients are refractory to standard medical or endoscopic treatments. Total pancreatectomy (TP) and islet auto-transplantation (TP-IAT) can offer pain relief to patients by removing the entire pancreas and the auto-transplant component ameliorates the resulting diabetes. QoL is significantly improved after TP-IAT when insulin independence is present. Recent data support offering TP-IAT rather than TP alone and treating with exogenous insulin for patients with debilitating chronic pancreatitis.

• Authors: Melena D Bellin, Karthik Ramanathan, Srinath Chinnakotla
• Journal: Advances in surgery (Adv Surg) Vol. 57 Issue 1 Pg. 15-30 (09 2023) ISSN: 1878-0555 [Electronic] United States
• PMID: 37536850 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2023 Elsevier Inc. All rights reserved.

Chemical References

• Insulin
• Insulin, Regular, Human

Topics

• Humans
• Pancreatectomy (methods)
• Quality of Life
• Treatment Outcome
• Pancreatitis, Chronic (surgery)
• Islets of Langerhans Transplantation (methods)
• Insulin
• Transplantation, Autologous
• Insulin, Regular, Human