Role of BDNF-TrkB signaling in the antidepressant-like actions of loganin, the main active compound of Corni Fructus.

Abstract

AIMS:

Corni Fructus (CF) and some CF-contained prescriptions are commonly used in clinical treatment of depression. This investigation aims to evaluate the main active compound of CF in antidepressant properties and its key target.

METHODS:

Firstly, this study established a behavioral despair model and used high-performance liquid chromatography method to evaluate the antidepressant-like effects of water extract, 20%, 50%, and 80% ethanol extracts of CF, and its main active compound. Then, this study created chronic unpredictable mild stress (CUMS) model to assess loganin's antidepressant-like properties, and its target was evaluated by quantitative real-time polymerase chain reaction, Western blot, Immunofluorescence, enzyme-linked immunosorbent assay, and tyrosine receptor kinase B (TrkB) inhibitor.

RESULTS:

Results showed that the different extracts of CF significantly shortened the immobility time in forced swimming and tail suspension tests. Moreover, loganin alleviated CUMS-induced depression-like behavior, promoted neurotrophy and neurogenesis, and inhibited neuroinflammation. Furthermore, K252a blocked the improvement of loganin on depression-like behavior, and eliminated the enhancement of neurotrophy and neurogenesis and the inhibition of neuroinflammation.

CONCLUSION:

Overall, these results indicated that loganin could be used as a major active compound of CF for the antidepressant-like properties and exerted antidepressant-like actions by regulating brain derived neurotrophic factor (BDNF)-TrkB signaling, and TrkB could be used as key target for itsantidepressant-like actions.

• Authors: Mingzhu Gong, Junming Wang, Lingling Song, Xiaohui Wu, Yanmei Wang, Bingyin Li, Yueyue Zhang, Lingyu Qin, Yaqian Duan, Bingyu Long
• Journal: CNS neuroscience & therapeutics (CNS Neurosci Ther) Vol. 29 Issue 12 Pg. 3842-3853 (Dec 2023) ISSN: 1755-5949 [Electronic] England
• PMID: 37408379 (Publication Type: Journal Article)
• Copyright: © 2023 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.

Chemical References

• Brain-Derived Neurotrophic Factor
• loganin
• Receptor, trkB
• Antidepressive Agents

Topics

• Animals
• Brain-Derived Neurotrophic Factor (metabolism)
• Cornus (metabolism)
• Receptor, trkB
• Neuroinflammatory Diseases
• Antidepressive Agents (pharmacology, therapeutic use)
• Depression (drug therapy)
• Stress, Psychological (drug therapy)
• Hippocampus (metabolism)
• Disease Models, Animal