loganin

in many plants; glycosylation transforms the hemiacetal linkage to an acetal; a precursor to secologanin and TRYPTAMINE; a component of cornel iridoid glycoside; RN given refers to (1S-(1alpha,4aalpha,6alpha,7alpha,7aalpha))-isomer

Also Known As:

Networked: 78 relevant articles (16 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Park, Chan Hum: 4 articles (06/2016 - 12/2010)
2.	Yokozawa, Takako: 4 articles (06/2016 - 12/2010)
3.	He, Jun: 3 articles (06/2022 - 01/2019)
4.	Lian, Wen-Wen: 3 articles (06/2022 - 01/2019)
5.	Xia, Cong-Yuan: 3 articles (06/2022 - 01/2019)
6.	Xu, Jie-Kun: 3 articles (06/2022 - 01/2019)
7.	Yan, Yu: 3 articles (06/2022 - 01/2019)
8.	Zhang, Wei-Ku: 3 articles (06/2022 - 01/2019)
9.	Song, Gang: 3 articles (03/2022 - 04/2020)
10.	Cheng, Yu-Chi: 3 articles (11/2021 - 02/2020)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2023 - "In summary, these findings imply that loganin may be a novel nutritional and therapeutic treatment for NASH-related inflammation." 12/05/2021 - "The present study was designed to predict the potential targets of loganin against inflammation-associated depression using a network pharmacology approach. " 12/01/2018 - "The present study was aimed to investigate effects of loganin on Aβ-induced inflammation and to explore the underlying mechanisms. " 08/01/2022 - "This work demonstrated that loganin inhibited IL-1β-mediated inflammation in rat chondrocytes through TLR4/MyD88/NF-κB pathway regulation, thereby reducing rat cartilage degeneration and the synovial inflammatory response." 08/01/2022 - "This work aimed to explore loganin's role and molecular mechanism in inflammation and clarify its anti-inflammatory effects in OA treatment. "
2.	Diabetes Complications 06/01/2015 - "Our results clearly indicate that loganin and 7-O-galloyl-D-sedoheptulose have great promise for the treatment of diabetic complications through inhibition of AR. " 06/01/2015 - "In this study, we evaluated whether two major compounds of Corni Fructus, loganin and 7-O-galloyl-D-sedoheptulose, had an inhibitory effect on diabetic complications through AR inhibition. " 12/01/2010 - "Loganin exhibits protective effects against hepatic injury and other diabetic complications associated with abnormal metabolic states and inflammation caused by oxidative stress and advanced glycation endproduct formation." 06/01/2015 - "Kinetic and molecular docking studies of loganin and 7-O-galloyl-D-sedoheptulose from Corni Fructus as therapeutic agents for diabetic complications through inhibition of aldose reductase." 06/01/2015 - "Because the iridoid glycoside loganin and the low-molecular-weight polyphenol 7-O-galloyl-D-sedoheptulose showed marginal inhibitory activities against rat lens AR (RLAR) and human recombinant AR (HRAR) in inhibition assays, we performed enzyme kinetic analyses and molecular simulation of the interaction of these two compounds with AR to further investigate their potential as inhibitors of diabetic complications. "
3.	Hyperalgesia 11/01/2021 - "Loganin prevented CCI-attenuated PWT and PWL, suggesting improved mechanical allodynia and thermal hyperalgesia. " 02/01/2020 - "Thermal hyperalgesia and mechanical allodynia were reduced in the loganin-treated group as compared to the CCI group. " 10/08/2021 - "Loganin improved PDN rats' associated pain behaviors (allodynia and hyperalgesia), insulin resistance index (HOMA-IR), and serum levels of superoxide dismutase (SOD), catalase and glutathione. "
4.	Sepsis (Septicemia) 01/01/2021 - "The results suggested that the protective effects of Loganin on AKI during sepsis might be mediated by AKT and Nrf2/HO-1 pathway signaling activation in kidney proximal tubular cells." 06/01/2021 - "Our study offers a favorable mechanistic basis to support the therapeutic potential of loganin in anti-inflammatory diseases, such as sepsis-induced ALI." 01/01/2021 - "The primary aim of this study was to evaluate whether Loganin could alleviate acute kidney injury (AKI) during sepsis and investigate the latent mechanisms. " 06/01/2021 - "In the current study, the cecal ligation and puncture (CLP)-induced murine sepsis model was constructed to investigate the anti-inflammatory property of loganin in sepsis-induced ALI. " 06/01/2021 - "Taken together, the anti-inflammatory effect of loganin in sepsis-induced ALI was associated with the ERK and NF-κB pathway-mediated macrophage polarization and NLRP3 inflammasome activation. "
5.	Diabetic Nephropathies (Diabetic Nephropathy) 02/15/2015 - "Loganin improved diabetic nephropathy in vivo associated with inhibition of AGE pathways, and could be a promising remedy for diabetic nephropathy." 09/01/2023 - "The purpose of this study was to investigate the protective effect of loganin on diabetic nephropathy in vivo and in vitro and whether this effect was related to the inhibition of pyroptosis. " 05/01/2021 - "Loganin alleviates macrophage infiltration and activation by inhibiting the MCP-1/CCR2 axis in diabetic nephropathy." 02/15/2015 - "We herein evaluated the effects of loganin on diabetic nephropathy in vivo. " 05/14/2014 - "The results suggested that loganin and its derivatives were the active compounds in Cornus officinalis fruit (Shanzhuyu) on diabetic nephropathy. "

Related Drugs and Biologics

1.	morroniside
2.	7-O-galloyl-D-sedoheptulose
3.	Iridoids
4.	Glycosides
5.	catalpol
6.	Advanced Glycation End Products
7.	Interleukin-6 (Interleukin 6)
8.	Streptozocin (Streptozotocin)
9.	Superoxide Dismutase
10.	Salts

Related Therapies and Procedures

1.	Oral Administration
2.	Ovariectomy (Oophorectomy)
3.	Punctures
4.	Ligation
5.	Immunomodulation